E3 ligase Ligand 1

• CAT Number: I013139
• CAS Number: 1948273-03-7
• Molecular Formula: C23H33ClN4O3S
• Molecular Weight: 481.05
• Purity: ≥95%
• Target: Ligand for E3 Ligase
• Solubility: DMSO
• IUPAC Name: (2S,4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide;hydrochloride
• InChI: InChI=1S/C23H32N4O3S.ClH/c1-13(15-6-8-16(9-7-15)19-14(2)25-12-31-19)26-21(29)18-10-17(28)11-27(18)22(30)20(24)23(3,4)5;/h6-9,12-13,17-18,20,28H,10-11,24H2,1-5H3,(H,26,29);1H/t13-,17+,18-,20+;/m0./s1
• InChIKey: GHFOLQCCYGBOTL-QDVBFIRISA-N
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)C(C)NC(=O)C3CC(CN3C(=O)C(C(C)(C)C)N)O.Cl

E3 ligase Ligand 1 (CAT: I013139) is a small molecule ligand for E3 ligase, which has been used as a tool compound for the development of PROTACs (Proteolysis-Targeting Chimeras). PROTACs are bifunctional molecules that recruit an E3 ubiquitin ligase to a specific target protein, leading to the ubiquitination and subsequent degradation of the target protein by the proteasome. The use of E3 ligase Ligand 1 in PROTAC technology allows for the specific degradation of disease-causing proteins, making it a promising therapeutic approach for various diseases.

Reference

[1]. WO/2017/030814A1
[2]. Kanak R, et al. PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer. Proceedings of the National Academy of Sciences of the United States of America (2016), 113(26), 7124-7129