E3 ligase Ligand 9

• CAT Number: I018633
• CAS Number: 87304-15-2
• Molecular Formula: C₂₁H₃₂N₂O₆
• Molecular Weight: 408.49
• Purity: ≥95%
• Target: Ligands for E3 Ligase

E3 Ligase Ligand 9(CAT: I018633) holds paramount significance in the realm of targeted protein degradation and drug discovery. As a ligand for E3 ubiquitin ligase, E3 Ligase Ligand 9 plays a pivotal role in mediating the ubiquitination and subsequent degradation of specific proteins within cells. Its unique property of forming a connection between the ligand and the target protein through a linker facilitates the creation of powerful therapeutic agents known as PROTACs (PROteolysis TAgeting Chimeras) or SNIPERs (Specific and Nongenetic IAP-dependent Protein Erasers).

Reference

[1]. Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575.