E3 Ligase Ligand-Linker Conjugates 21

• CAT Number: I013172
• CAS Number: 1957236-20-2
• Molecular Formula: C₂₃H₃₀N₄O₉
• Molecular Weight: 506.51
• Purity: ≥95%
• Target: Autophagy
• Solubility: DMSO
• IUPAC Name: N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide
• InChI: InChI=1S/C23H30N4O9/c24-6-8-33-10-12-35-13-11-34-9-7-25-19(29)14-36-17-3-1-2-15-20(17)23(32)27(22(15)31)16-4-5-18(28)26-21(16)30/h1-3,16H,4-14,24H2,(H,25,29)(H,26,28,30)
• InChIKey: QIUJTJGNIBUEJO-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCC(=O)NCCOCCOCCOCCN

E3 Ligase Ligand-Linker Conjugates 21(CAT: I013172) are advanced chemical tools used in PROTAC (Proteolysis Targeting Chimera) technology to induce targeted protein degradation. These conjugates consist of an E3 ligase ligand that recruits the ubiquitin-proteasome system, a flexible linker, and a site for attaching ligands targeting specific proteins. By promoting ubiquitination of disease-related proteins, they enable selective and efficient degradation. This mechanism offers a novel therapeutic strategy in oncology, neurodegenerative disease, and drug discovery research, particularly for targeting “undruggable” proteins, enhancing precision medicine approaches, and advancing treatments for complex diseases.