For research use only. Not for therapeutic Use.
E6446 hydrochloride(CAT: I014350) is a synthetic compound designed as an antagonist for nucleic acid-sensing Toll-like receptors (TLRs). By targeting these receptors, E6446 interferes with the recognition and response to nucleic acids, which play a pivotal role in the immune system’s defense against pathogens. The compound’s ability to antagonize TLRs suggests its potential as an immunomodulatory agent that may help regulate immune responses and inflammation.
| Catalog Number | I014350 |
| CAS Number | 1345675-25-3 (HCl) |
| Synonyms | E6446 HCl; E6446; E-6446; E6446 hydrochloride;6-(3-pyrrolidin-1-ylpropoxy)-2-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-1,3-benzoxazole;dihydrochloride |
| Molecular Formula | C27H37Cl2N3O3 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| InChI | InChI=1S/C27H35N3O3.2ClH/c1-2-14-29(13-1)17-5-19-31-23-9-7-22(8-10-23)27-28-25-12-11-24(21-26(25)33-27)32-20-6-18-30-15-3-4-16-30;;/h7-12,21H,1-6,13-20H2;2*1H |
| InChIKey | DQOUZINBHKWGGM-UHFFFAOYSA-N |
| SMILES | [H]Cl.[H]Cl.C1(C2=CC=C(OCCCN3CCCC3)C=C2)=NC4=CC=C(OCCCN5CCCC5)C=C4O1 |
| Reference | </br>1: Franklin BS, Ishizaka ST, Lamphier M, Gusovsky F, Hansen H, Rose J, Zheng W,</br> Ataíde MA, de Oliveira RB, Golenbock DT, Gazzinelli RT. Therapeutical targeting</br> of nucleic acid-sensing Toll-like receptors prevents experimental cerebral</br> malaria. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3689-94. doi:</br> 10.1073/pnas.1015406108. Epub 2011 Feb 8. PubMed PMID: 21303985; PubMed Central</br> PMCID: PMC3048158.</br> </br> |
