E7449 mesylate

• CAT Number: I047669
• CAS Number: 1140965-47-4
• Molecular Formula: C18H15N5O.CH4O3S
• Molecular Weight: 413.45
• Purity: ≥95%
• IUPAC Name: 11-(1,3-dihydroisoindol-2-ylmethyl)-2,3,10,12-tetrazatricyclo[7.3.1.05,13]trideca-1,5(13),6,8,11-pentaen-4-one;methanesulfonic acid
• InChI: InChI=1S/C18H15N5O.CH4O3S/c24-18-13-6-3-7-14-16(13)17(21-22-18)20-15(19-14)10-23-8-11-4-1-2-5-12(11)9-23;1-5(2,3)4/h1-7H,8-10H2,(H,22,24)(H,19,20,21);1H3,(H,2,3,4)
• SMILES: CS(=O)(=O)O.C1C2=CC=CC=C2CN1CC3=NC4=NNC(=O)C5=C4C(=CC=C5)N3

E7449 mesylate is a potent, brain penetrable and orally bioavailable dual inhibitor of PARP1/2 and tankyrase1/2, which inhibits growth of DNA repair deficient tumors and antagonizes Wnt signalling. E7449 mesylate exhibits IC50 values of 2.0 and 1.0 nM for PARP1 and PARP2, respectively.
KEYWORDS: E7449 mesylate | Supplier | PARP1/2-TNKS1/2 inhibitor | 2X-121 | E 7449 mesylate | E-7449 mesylate | CAS [1140965-47-4] | [1140964-99-3] | DNA-RNA | PARP | TNKS | Inhibitor | Enzymes

Reference

S McGonigle et al. E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling. Oncotarget. 2015 Dec 1;6(38):41307-23.