For research use only. Not for therapeutic Use.
EA4, a derivative of quinone, is an inhibitor for both rPLA and cPLA. EA4 can inhibit rPLA2 with a Ki value of 130 μM. EA4 can be used for the research of hemostasis, thrombosis, and erythropoiesis[1].
EA4 (9 μM, 24 μM) inhibits both rPLA2 and cPLA2[1].
EA4 can inhibit rPLA2 with a Ki value of 130 μM[1].
EA4 (50 μM) significantly inhibits A23187-induced AA release from both human and bovine RBCs in a time-dependent manner[1].
| Catalog Number | I011737 |
| CAS Number | 389614-94-2 |
| Synonyms | 7-chloro-6-[4-(diethylamino)phenyl]quinoline-5,8-dione |
| Molecular Formula | C19H17ClN2O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H17ClN2O2/c1-3-22(4-2)13-9-7-12(8-10-13)15-16(20)19(24)17-14(18(15)23)6-5-11-21-17/h5-11H,3-4H2,1-2H3 |
| InChIKey | XAZVKSMDPVMMPP-UHFFFAOYSA-N |
| SMILES | CCN(CC)C1=CC=C(C=C1)C2=C(C(=O)C3=C(C2=O)C=CC=N3)Cl |
| Reference | [1]. Shin, Hae Sook et al. Purification and characterization of a cytosolic, 42-kDa and Ca2+-dependent phospholipase A2 from bovine red blood cells: its involvement in Ca2+-dependent release of arachidonic acid from mammalian red blood cells. The Journal of biological chemistry vol. 277,23 (2002): 21086-94. |
