EACC

• CAT Number: I017944
• CAS Number: 864941-31-1
• Molecular Formula: C₁₃H₁₁N₃O₆S₂
• Molecular Weight: 369.37
• Purity: ≥95%
• Target: Autophagy

EACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion[1].EACC blocks autophagosome-lysosome fusion but does not affect endo-lysosomal function[1].
EACC inhibits autophagy by preventing SNARE Stx17 loading on autophagosomes[1].
EACC does not affect RABs, tethers, and lysosomal SNARE but prevents their interaction with LC3 and Stx17[1].

Reference

[1]. Vats S, et al. A reversible autophagy inhibitor blocks autophagosome-lysosome fusion by preventing Stx17 loading onto autophagosomes. Mol Biol Cell. 2019 Aug 1;30(17):2283-2295.