For research use only. Not for therapeutic Use.
EB-3D(Cat No.:I017227)is a selective inhibitor of the serine/threonine-protein kinase Akt, which plays a critical role in cell survival, growth, and metabolism. By inhibiting Akt, EB-3D disrupts key signaling pathways involved in cancer cell proliferation and survival, making it a valuable tool in oncology research. This compound has shown promise in preclinical studies targeting tumors with hyperactivated Akt signaling. EB-3D’s ability to modulate cancer cell metabolism and growth pathways makes it a potential candidate for exploring targeted therapies in cancer treatment.
Catalog Number | I017227 |
CAS Number | 1839150-63-8 |
Molecular Formula | C₃₀H₃₆Br₂N₄O₂ |
Purity | ≥95% |
Target | Epigenetics |
Storage | Inert atmosphere,Room Temperature |
IUPAC Name | 1-[[4-[2-[4-[[4-(dimethylamino)pyridin-1-ium-1-yl]methyl]phenoxy]ethoxy]phenyl]methyl]-N,N-dimethylpyridin-1-ium-4-amine;dibromide |
InChI | InChI=1S/C30H36N4O2.2BrH/c1-31(2)27-13-17-33(18-14-27)23-25-5-9-29(10-6-25)35-21-22-36-30-11-7-26(8-12-30)24-34-19-15-28(16-20-34)32(3)4;;/h5-20H,21-24H2,1-4H3;2*1H/q+2;;/p-2 |
InChIKey | SCXVGPSPZQBBDM-UHFFFAOYSA-L |
SMILES | CN(C)C1=CC=[N+](C=C1)CC2=CC=C(C=C2)OCCOC3=CC=C(C=C3)C[N+]4=CC=C(C=C4)N(C)C.[Br-].[Br-] |
Reference | [1]. Mariotto E, et al. EB-3D a novel choline kinase inhibitor induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells. Biochem Pharmacol. 2018 Sep;155:213-223.<br>[2]. Sola-Leyva A, et al. Choline kinase inhibitors EB-3D and EB-3P interferes with lipid homeostasis in HepG2 cells. Sci Rep. 2019 Mar 25;9(1):5109.<br>[3]. Schiaffino-Ortega S, et al. Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1).<br>[4]. Mariotto E, et al. Choline Kinase Alpha Inhibition by EB-3D Triggers Cellular Senescence, Reduces Tumor Growth and Metastatic Dissemination in Breast Cancer. Cancers (Basel). 2018;10(10):391. Published 2018 Oct 22. |