EBE-A22

• CAT Number: I002750
• CAS Number: 229476-53-3
• Molecular Formula: C17H16BrN3O2
• Molecular Weight: 374.23
• Purity: ≥95%
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: N-(3-bromophenyl)-6,7-dimethoxy-N-methylquinazolin-4-amine
• InChI: InChI=1S/C17H16BrN3O2/c1-21(12-6-4-5-11(18)7-12)17-13-8-15(22-2)16(23-3)9-14(13)19-10-20-17/h4-10H,1-3H3
• InChIKey: IPWGDOZPSOZFOD-UHFFFAOYSA-N
• SMILES: CN(C1=CC(=CC=C1)Br)C2=NC=NC3=CC(=C(C=C32)OC)OC

EBE-A22（Cat No.: I002750）, is a derivative of PD 153035. While PD 153035 is known for its ability to inhibit the phosphorylation of ErbB-1 (also known as EGFR), EBE-A22 does not exhibit this property. The differentiation between these compounds in terms of ErbB-1 phosphorylation inhibition suggests that EBE-A22 may have unique characteristics or molecular interactions, making it valuable for research aimed at understanding receptor tyrosine kinase signaling pathways. Should you require further information or support regarding EBE-A22, please do not hesitate to contact us.

Reference

[1]. Goossens JF, et al. DNA interaction of the tyrosine protein kinase inhibitor PD153035 and its N-methyl analogue. Biochemistry. 2001 Apr 17;40(15):4663-71.