EC144

For research use only. Not for therapeutic Use.

  • CAT Number: R015937
  • CAS Number: 911397-80-3
  • Molecular Formula: C21H24ClN5O2
  • Molecular Weight: 413.90
  • Purity: ≥95%
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EC144 is a potent and selective inhibitor of heat shock protein 90 (Hsp90) with an IC50 of 1.1 nM. EC144 inhibits tumor growth and causes partial tumor regressions. EC144 has the potential for the research of cancer diseases[1]. EC144 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.


Catalog Number R015937
CAS Number 911397-80-3
Synonyms

5-[2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]pyrrolo[2,3-d]pyrimidin-5-yl]-2-methylpent-4-yn-2-ol

Molecular Formula C21H24ClN5O2
Purity ≥95%
InChI InChI=1S/C21H24ClN5O2/c1-12-9-24-15(13(2)17(12)29-5)11-27-10-14(7-6-8-21(3,4)28)16-18(22)25-20(23)26-19(16)27/h9-10,28H,8,11H2,1-5H3,(H2,23,25,26)
InChIKey VOASEWXFCTZRDF-UHFFFAOYSA-N
SMILES CC1=CN=C(C(=C1OC)C)CN2C=C(C3=C2N=C(N=C3Cl)N)C#CCC(C)(C)O
Reference

[1]. Shi J, et al. EC144 is a potent inhibitor of the heat shock protein 90. J Med Chem. 2012;55(17):7786-7795.
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