Echothiophate Iodide

• CAT Number: I006584
• CAS Number: 513-10-0
• Molecular Formula: C9H23INO3PS
• Molecular Weight: 383.23
• Purity: ≥95%
• Synonyms: Echothiophate Iodide; Phospholine iodide; Ecothiophate iodide; Echodide; Ecostigmini Sodidum; Iodide, Echothiophate; Iodide, Ecothiopate; Iodide, Ecothiophate; Iodide, Phospholine; Phospholine Iodide;;2-diethoxyphosphorylsulfanylethyl(trimethyl)azani
• Target: Cholinesterase (ChE)
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4°C for short term or -20 °C for long term
• IUPAC Name: 2-diethoxyphosphorylsulfanylethyl(trimethyl)azanium;iodide
• InChI: InChI=1S/C9H23NO3PS.HI/c1-6-12-14(11,13-7-2)15-9-8-10(3,4)5;/h6-9H2,1-5H3;1H/q+1;/p-1
• InChIKey: OVXQHPWHMXOFRD-UHFFFAOYSA-M
• SMILES: CCOP(=O)(OCC)SCC[N+](C)(C)C.[I-]

Echothiophate iodide (Cat No.: I006584) is a long-acting cholinesterase inhibitor used in ophthalmic research for conditions such as glaucoma and accommodative esotropia. By inhibiting acetylcholinesterase, it prolongs acetylcholine activity, leading to sustained pupil constriction (miosis) and reduced intraocular pressure. Its irreversible mechanism makes it a valuable tool for studying cholinergic neurotransmission and ocular pharmacology. Echothiophate iodide is also investigated for its effects on neuromuscular function, offering insights into potential treatments for myasthenia gravis and other cholinergic disorders.

Overview of Clinical Research

The phase III trial to investigate the efficacy and safety Echothiophate Iodide in patients with Stargardt's disease was completed in 2015. 

Reference

1: Gorin G. Echothiophate iodide for glaucoma or flat anterior chamber following cataract extraction. Am J Ophthalmol. 1969 Mar;67(3):392-5. PubMed PMID: 5774254.
2: Hussain A, Schurman P, Peter V, Milosovich G. Kinetics and mechanism of degradation of echothiophate iodide in aqueous solution. J Pharm Sci. 1968 Mar;57(3):411-8. PubMed PMID: 5655578.
3: Hiscox PE, McCulloch C. Cardiac arrest occurring in a patient on echothiophate iodide therapy. Am J Ophthalmol. 1965 Sep;60(3):425-7. PubMed PMID: 5825146.
4: HUMPHREYS JA, HOLMES JH. Systemic effects produced by echothiophate iodide in treatment of glaucoma. Arch Ophthalmol. 1963 Jun;69:737-43. PubMed PMID: 13955705.
5: HILL K, STROMBERG AE. Echothiophate iodide in the management of esotropia. Am J Ophthalmol. 1962 Mar;53:488-94. PubMed PMID: 13907355.
6: BECKER B, GAGE T. Demecarium bromide and echothiophate iodide in chronic glaucoma. Arch Ophthalmol. 1960 Jan;63:102-7. PubMed PMID: 13798061.