Econazole Nitrate

For research use only. Not for therapeutic Use.

  • CAT Number: A000795
  • CAS Number: 24169-02-6
  • Molecular Formula: C18H16Cl3N3O4
  • Molecular Weight: 444.70
  • Purity: ≥95%
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Econazole Nitrate(Cat No.:A000795)is an antifungal agent used primarily in the treatment of dermatophyte infections, including athlete’s foot, ringworm, and candidiasis. It works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, thereby disrupting the integrity of the cell membrane and causing fungal cell death. This imidazole derivative is topically applied and is effective against a broad spectrum of fungal pathogens. Econazole Nitrate is commonly found in cream, ointment, and solution formulations, offering a reliable solution for localized skin infections.


Catalog Number A000795
CAS Number 24169-02-6
Synonyms

24169-02-6; Ifenec; Epi-pevaryl; Gyno-pevaryl; Pevaryl

Molecular Formula C18H16Cl3N3O4
Purity ≥95%
Target Fungal
Storage -20°C
IUPAC Name 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole;nitric acid
InChI InChI=1S/C18H15Cl3N2O.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)
InChIKey DDXORDQKGIZAME-UHFFFAOYSA-N
SMILES C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl.[N+](=O)(O)[O-]
Reference

1: Shah RM, Eldridge DS, Palombo EA, Harding IH. Microwave-assisted microemulsion
technique for production of miconazole nitrate- and econazole nitrate-loaded
solid lipid nanoparticles. Eur J Pharm Biopharm. 2017 Aug;117:141-150. doi:
10.1016/j.ejpb.2017.04.007. Epub 2017 Apr 12. PubMed PMID: 28411057.
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2: Abd El-Gawad AEH, Soliman OA, El-Dahan MS, Al-Zuhairy SAS. Improvement of the
Ocular Bioavailability of Econazole Nitrate upon Complexation with Cyclodextrins.
AAPS PharmSciTech. 2017 Jul;18(5):1795-1809. doi: 10.1208/s12249-016-0609-9. Epub
2016 Nov 9. PubMed PMID: 27830515.
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3: Su&#241;er-Carbó J, Boix-Monta&#241;és A, Halbaut-Bellowa L, Velázquez-Carralero N,
Zamarbide-Ledesma J, Bozal-de-Febrer N, Calpena-Campmany AC. Skin permeation of
econazole nitrate formulated in an enhanced hydrophilic multiple emulsion.
Mycoses. 2017 Mar;60(3):166-177. doi: 10.1111/myc.12575. Epub 2016 Oct 20. PubMed
PMID: 27761948.
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4: Fleischer AB Jr, Raymond I. Econazole Nitrate Foam 1% Improves the Itch of
Tinea Pedis. J Drugs Dermatol. 2016 Sep 1;15(9):1111-4. PubMed PMID: 27602974.

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5: Maged A, Mahmoud AA, Ghorab MM. Nano Spray Drying Technique as a Novel
Approach To Formulate Stable Econazole Nitrate Nanosuspension Formulations for
Ocular Use. Mol Pharm. 2016 Sep 6;13(9):2951-65. doi:
10.1021/acs.molpharmaceut.6b00167. Epub 2016 Mar 31. PubMed PMID: 27010795.
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6: Ren Y, Zhang Q, Yu Z. [Clinical analysis of external ear canal coating by
otoendoscopy on otomycosis external with triamcinolone acetonide and econazole
nitrate cream]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015
Jul;29(14):1304-5. Chinese. PubMed PMID: 26672250.
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7: Sun J, Yu CH, Zhao XL, Wang Y, Jiang SG, Gong XF. Econazole Nitrate Induces
Apoptosis in MCF-7 Cells via Mitochondrial and Caspase Pathways. Iran J Pharm
Res. 2014 Fall;13(4):1327-34. PubMed PMID: 25587322; PubMed Central PMCID:
PMC4232799.
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8: Chen Z, Li X, Wu X, Wang W, Wang W, Xin M, Shen F, Liu L, Liang J, Li L, Yu L.
Synergistic Activity of Econazole-Nitrate and Chelerythrine against Clinical
Isolates of Candida albicans. Iran J Pharm Res. 2014 Spring;13(2):567-73. PubMed
PMID: 25237352; PubMed Central PMCID: PMC4157032.

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9: Elewski BE, Vlahovic TC. Econazole nitrate foam 1% for the treatment of tinea
pedis: results from two double-blind, vehicle-controlled, phase 3 clinical
trials. J Drugs Dermatol. 2014 Jul;13(7):803-8. PubMed PMID: 25007362.
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10: Gajra B, Pandya SS, Singh S, Rabari HA. Mucoadhesive hydrogel films of
econazole nitrate: formulation and optimization using factorial design. J Drug
Deliv. 2014;2014:305863. doi: 10.1155/2014/305863. Epub 2014 Jun 10. PubMed PMID:
25006462; PubMed Central PMCID: PMC4071986.

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