For research use only. Not for therapeutic Use.
<span>Econazole nitrate is an insoluble (0.00148 mg/mL) imidazole antifungal that specifically targets the cell membrane of fungi.</span></br>Econazole nitrate increases cell permeability by inhibiting enzymes involved in ergosterol synthesis. The increase of permeability has a toxic effect on the fungi and leads to cell death.
| Catalog Number | R004201 |
| CAS Number | 68797-31-9 |
| Molecular Formula | C18H16Cl3N3O4 |
| Purity | ≥95% |
| Storage | 2-8°C |
| IUPAC Name | 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole;nitric acid |
| InChI | InChI=1S/C18H15Cl3N2O.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4) |
| InChIKey | DDXORDQKGIZAME-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl.[N+](=O)(O)[O-] |
| Reference | <p>Rice, Louis B., and Mahmoud A. Ghannoum. /Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance./ Clinical Microbiology Reviews (1999): 501-17. www.ncbi.gov. Oct. 1999. Web. 22 Aug. 2012.</p><p>Bygrave, F. L., R. Fulceri, and A. Benedetti. /On the Mechanism of Action of Econazole, the Capacitative Calcium Inflow Blocker./ PubMed (1998): 75-77. Web. 22 Aug. 2012.</p></span></p> |
