Ecopladib

• CAT Number: I020644
• CAS Number: 381683-92-7
• Molecular Formula: C₃₉H₃₃Cl₃N₂O₅S
• Molecular Weight: 748.11
• Purity: ≥95%
• Target: Phospholipase
• IUPAC Name: 4-[2-[1-benzhydryl-5-chloro-2-[2-[(3,4-dichlorophenyl)methylsulfonylamino]ethyl]indol-3-yl]ethoxy]benzoic acid
• InChI: InChI=1S/C39H33Cl3N2O5S/c40-30-14-18-36-33(24-30)32(20-22-49-31-15-12-29(13-16-31)39(45)46)37(19-21-43-50(47,48)25-26-11-17-34(41)35(42)23-26)44(36)38(27-7-3-1-4-8-27)28-9-5-2-6-10-28/h1-18,23-24,38,43H,19-22,25H2,(H,45,46)
• InChIKey: FMMCHWHNSUBYAV-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)N3C4=C(C=C(C=C4)Cl)C(=C3CCNS(=O)(=O)CC5=CC(=C(C=C5)Cl)Cl)CCOC6=CC=C(C=C6)C(=O)O

Ecopladib (Cat.No:I020644) is a potent and selective inhibitor of the enzyme secretory phospholipase A2 (sPLA2). It has anti-inflammatory properties and is being investigated for its potential therapeutic applications in conditions such as cardiovascular diseases and acute pancreatitis. Further research is ongoing to explore its efficacy and safety profiles. 

Reference

[1]. Lee KL, et al. Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha. J Med Chem. 2007 Mar 22;50(6):1380-400. Epub 2007 Feb 17.