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89-25-8-Edaravone Edaravone

Edaravone

For research use only. Not for therapeutic Use.

  • CAT Number: A000382
  • CAS Number: 89-25-8
  • Molecular Formula: C10H10N2O
  • Molecular Weight: 174.20
  • Purity: ≥95%
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Related Small Molecules: Enoxaparin sodium     2-Hydroxy-4-methoxybenzaldehyde     5-Bromocytosine    
Research Areas: Oxidative Stress Modulation    

Edaravone（Cat No.:A000382）is a neuroprotective agent primarily used to treat amyotrophic lateral sclerosis (ALS) and is known for its potent antioxidant properties. It works by scavenging free radicals, reducing oxidative stress, and preventing neuronal cell damage, which are critical factors in neurodegenerative diseases. Edaravone’s ability to mitigate oxidative damage also shows potential in treating acute ischemic stroke, where it helps limit injury to brain tissue. Due to its unique action on oxidative pathways, it is a significant therapeutic and research compound in neurology and neuroprotection studies.


Catalog Number A000382
CAS Number 89-25-8
Synonyms

89-25-8; 3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE; Norphenazone; Radicut; 1-Phenyl-3-methyl-5-pyrazolone

Molecular Formula C10H10N2O
Purity ≥95%
Target Apoptosis
Storage -20°C
IUPAC Name 5-methyl-2-phenyl-4H-pyrazol-3-one
InChI InChI=1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3
InChIKey QELUYTUMUWHWMC-UHFFFAOYSA-N
SMILES CC1=NN(C(=O)C1)C2=CC=CC=C2
Reference

1: Wang X, Lai R, Su X, Chen G, Liang Z. Edaravone attenuates
lipopolysaccharide-induced acute respiratory distress syndrome associated early
pulmonary fibrosis via inhibition of oxidative stress and transforming growth
factor-β1/Smad3 signaling. Biochem Biophys Res Commun. 2017 Nov 1. pii:
S0006-291X(17)32152-6. doi: 10.1016/j.bbrc.2017.10.165. [Epub ahead of print]
PubMed PMID: 29102631.
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2: Rothstein JD. Edaravone: A new drug approved for ALS. Cell. 2017 Nov
2;171(4):725. doi: 10.1016/j.cell.2017.10.011. PubMed PMID: 29100067.

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3: Zhang WW, Bai F, Wang J, Zheng RH, Yang LW, James EA, Zhao ZQ. Edaravone
inhibits pressure overload-induced cardiac fibrosis and dysfunction by reducing
expression of angiotensin II AT1 receptor. Drug Des Devel Ther. 2017 Oct
16;11:3019-3033. doi: 10.2147/DDDT.S144807. eCollection 2017. PubMed PMID:
29081650; PubMed Central PMCID: PMC5652925.

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4: Xu YP, Han F, Tan J. Edaravone protects the retina against
ischemia/reperfusion&#8209;induced oxidative injury through the PI3K/Akt/Nrf2 pathway.
Mol Med Rep. 2017 Oct 6. doi: 10.3892/mmr.2017.7739. [Epub ahead of print] PubMed
PMID: 29039497.

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5: Zhang X, Xu F, Liu L, Feng L, Wu X, Shen Y, Sun Y, Wu X, Xu Q. (+)-Borneol
improves the efficacy of edaravone against DSS-induced colitis by promoting M2
macrophages polarization via JAK2-STAT3 signaling pathway. Int Immunopharmacol.
2017 Dec;53:1-10. doi: 10.1016/j.intimp.2017.10.002. Epub 2017 Oct 10. PubMed
PMID: 29028547.
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6: Wang HM, Zhang T, Huang JK, Xiang JY, Chen JJ, Fu JL, Zhao YW. Edaravone
Attenuates the Proinflammatory Response in Amyloid-β-Treated Microglia by
Inhibiting NLRP3 Inflammasome-Mediated IL-1β Secretion. Cell Physiol Biochem.
2017 Oct 5;43(3):1113-1125. doi: 10.1159/000481753. [Epub ahead of print] PubMed
PMID: 28977782.

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7: Al-Chalabi A, Andersen PM, Chandran S, Chio A, Corcia P, Couratier P,
Danielsson O, de Carvalho M, Desnuelle C, Grehl T, Grosskreutz J, Holm&#248;y T, Ingre
C, Karlsborg M, Kleveland G, Koch JC, Koritnik B, KuzmaKozakiewicz M, Laaksovirta
H, Ludolph A, McDermott C, Meyer T, Mitre Ropero B, Mora Pardina J, Nygren I,
Petri S, Povedano Panades M, Salachas F, Shaw P, Silani V, Staaf G, Svenstrup K,
Talbot K, Tysnes OB, Van Damme P, van der Kooi A, Weber M, Weydt P, Wolf J,
Hardiman O, van den Berg LH. July 2017 ENCALS statement on edaravone. Amyotroph
Lateral Scler Frontotemporal Degener. 2017 Nov;18(7-8):471-474. doi:
10.1080/21678421.2017.1369125. Epub 2017 Oct 4. PubMed PMID: 28975816.
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8: Akiyama G, Azuchi Y, Guo X, Noro T, Kimura A, Harada C, Namekata K, Harada T.
Edaravone Prevents Retinal Degeneration in Adult Mice Following Optic Nerve
Injury. Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4908-4914. doi:
10.1167/iovs.17-22250. PubMed PMID: 28973341.

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9: Kapoor S. Edaravone and Its Protective Effects against Disease Progression in
Neurological Conditions Besides Strokes. J Stroke Cerebrovasc Dis. 2017 Sep 27.
pii: S1052-3057(17)30463-9. doi: 10.1016/j.jstrokecerebrovasdis.2017.08.042.
[Epub ahead of print] PubMed PMID: 28964649.
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10: Lin H, Ma X, Wang BC, Zhao L, Liu JX, Pu FF, Hu YQ, Hu HZ, Shao ZW. Edaravone
ameliorates compression-induced damage in rat nucleus pulposus cells. Life Sci.
2017 Nov 15;189:76-83. doi: 10.1016/j.lfs.2017.09.024. Epub 2017 Sep 20. PubMed
PMID: 28942283.

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