Edoxaban

For research use only. Not for therapeutic Use.

  • CAT Number: I003690
  • CAS Number: 480449-70-5
  • Molecular Formula: C24H30ClN7O4S
  • Molecular Weight: 548.06
  • Purity: ≥95%
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Edoxaban (Cat.No:I003690) is an oral anticoagulant medication used to prevent and treat blood clotting disorders. It belongs to the class of direct oral anticoagulants (DOACs) and acts by inhibiting factor Xa, a key component in the blood clotting cascade. Edoxaban is prescribed for conditions such as atrial fibrillation, deep vein thrombosis, and pulmonary embolism. 


Catalog Number I003690
CAS Number 480449-70-5
Synonyms

N/’-(5-chloropyridin-2-yl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide

Molecular Formula C24H30ClN7O4S
Purity ≥95%
Target Thrombin
Solubility DMSO 100 mg/ml; Water <1 mg/ml
Storage Store at -20°C
IUPAC Name N'-(5-chloropyridin-2-yl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide
InChI InChI=1S/C24H30ClN7O4S/c1-31(2)24(36)13-4-6-15(27-20(33)21(34)30-19-7-5-14(25)11-26-19)17(10-13)28-22(35)23-29-16-8-9-32(3)12-18(16)37-23/h5,7,11,13,15,17H,4,6,8-10,12H2,1-3H3,(H,27,33)(H,28,35)(H,26,30,34)/t13-,15-,17+/m0/s1
InChIKey HGVDHZBSSITLCT-JLJPHGGASA-N
SMILES CN1CCC2=C(C1)SC(=N2)C(=O)NC3CC(CCC3NC(=O)C(=O)NC4=NC=C(C=C4)Cl)C(=O)N(C)C
Reference

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<br>[1]. Mendell J, Lee F, Chen S, The Effects of the Antiplatelet Agents, Aspirin and Naproxen, on Pharmacokinetics and Pharmacodynamics of the Anticoagulant Edoxaban, a Direct Factor Xa Inhibitor. J Cardiovasc Pharmacol. 2013 Apr 23. [Epub ahead of print]
<br>[2]. Mendell J, Noveck RJ, Shi M. Pharmacokinetics of the direct factor Xa inhibitor edoxaban and digoxin administered alone and in combination. J Cardiovasc Pharmacol. 2012 Oct;60(4):335-41.
<br>[3]. Bathala MS, Masumoto H, Oguma T, Pharmacokinetics, biotransformation, and mass balance of edoxaban, a selective, direct factor Xa inhibitor, in humans. Drug Metab Dispos. 2012 Dec;40(12):2250-5.
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