For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>Edrophonium chloride (Cat.No:I000590) is a readily reversible acetylcholinesterase inhibitor; prevents breakdown of the neurotransmitter acetylcholine and acts by competitively inhibiting the enzyme acetylcholinesterase, mainly at the neuromuscular junction.</p>
| Catalog Number | I000590 |
| CAS Number | 116-38-1 |
| Synonyms | N-ethyl-3-hydroxy-N,N-dimethyl-benzenaminium, monochloride |
| Molecular Formula | C10H16NO • Cl |
| Purity | ≥95% |
| Target | Cholinesterase (ChE) |
| Solubility | DMSO: 31 mg/mL |
| Storage | Store at -20°C |
| IUPAC Name | ethyl-(3-hydroxyphenyl)-dimethylazanium;chloride |
| InChI | InChI=1S/C10H15NO.ClH/c1-4-11(2,3)9-6-5-7-10(12)8-9;/h5-8H,4H2,1-3H3;1H |
| InChIKey | BXKDSDJJOVIHMX-UHFFFAOYSA-N |
| SMILES | CC[N+](C)(C)C1=CC(=CC=C1)O.[Cl-] |
| Reference | </br>1:Upper eyelid retraction disclosed after edrophonium chloride administration in a patient with Graves/’ orbitopathy and myasthenia gravis. Kang H, Takahashi Y, Iwaki M, Asamura S, Kakizaki H.Clin Ophthalmol. 2012;6:807-10. doi: 10.2147/OPTH.S29408. Epub 2012 May 28. PMID: 22701081 Free PMC Article</br>2:The effect of cholinergic enhancement during filling cystometry: can edrophonium chloride be used as a provocative test for overactive bladder? Yossepowitch O, Gillon G, Baniel J, Engelstein D, Livne PM.J Urol. 2001 May;165(5):1441-5. PMID: 11342893 </br>3:[Edrophonium chloride (Tensilon) test: a safe method in diagnosing myasthenia gravis]. Domanovits H, Wenger S, Schillinger M, Mayr N, Holzer M, Laggner AN, Zeitlhofer J.Wien Klin Wochenschr. 2000 Jul 7;112(13):592-5. German. PMID: 10944818 </br>4:The effect of edrophonium chloride on muscle balance in normal subjects and those with nonmyasthenic strabismus. Siatkowski RM, Shah L, Feuer WJ.J Neuroophthalmol. 1997 Mar;17(1):7-11. PMID: 9093954 </br>5:The effect of edrophonium chloride-induced chest pain on esophageal blood flow and motility. Gustafsson U, Tibbling L.Scand J Gastroenterol. 1997 Feb;32(2):104-7. PMID: 9051868 </br>6:Edrophonium chloride for testing colonic contractile activity in man. Bassotti G, Imbimbo BP, Betti C, Erbella GS, Pelli MA, Morelli A.Acta Physiol Scand. 1991 Mar;141(3):289-93. PMID: 1858502 </br>7:Esophageal chest pain. Value of high-dose provocative testing with edrophonium chloride in patients with normal esophageal manometries. Lee CA, Reynolds JC, Ouyang A, Baker L, Cohen S.Dig Dis Sci. 1987 Jul;32(7):682-8. PMID: 3595381 </br>8:Myasthenia gravis: protective effect of ipratropiumbromide (Atrovent) on airways obstruction caused by edrophonium chloride (Tensilon). Szathmáry I, Magyar P, Szobor A.Eur Neurol. 1981;20(1):56-61. PMID: 6451430 </br>9:Determination of edrophonium chloride injection USP in the presence of preservatives. Hamill TW.J Assoc Off Anal Chem. 1979 Sep;62(5):1110-2. PMID: 528457 </br>10:Myasthenia gravis: lung-function studies without and with edrophonium chloride. Magyar P, Szathmáry I, Szobor A.Eur Neurol. 1979;18(1):59-65. PMID: 436864 |
