Eflornithine hydrochloride hydrate

• CAT Number: A000062
• CAS Number: 96020-91-6
• Molecular Formula: C6H12F2N2O2 • HCl [H2O]
• Molecular Weight: 236.60
• Purity: ≥95%
• Synonyms: Difluoromethylornithine hydrochloride hydrate
• Target: ornithine decarboxylase
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: 2,5-diamino-2-(difluoromethyl)pentanoic acid;hydrate;hydrochloride
• InChI: InChI=1S/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9;;/h4H,1-3,9-10H2,(H,11,12);1H;1H2
• InChIKey: FJPAMFNRCFEGSD-UHFFFAOYSA-N
• SMILES: C(CC(C(F)F)(C(=O)O)N)CN.O.Cl

Eflornithine Hydrochloride Hydrate（Cat No.:A000062）is an FDA-approved drug used to treat African trypanosomiasis (sleeping sickness) caused by Trypanosoma brucei gambiense. It works as an irreversible inhibitor of ornithine decarboxylase, a key enzyme in polyamine biosynthesis, disrupting parasite proliferation and survival. Eflornithine is also used topically for hirsutism to reduce unwanted facial hair growth by slowing follicular activity. Known for its safety and efficacy, Eflornithine is a critical therapeutic agent in neglected tropical disease management and dermatological conditions, with ongoing research exploring its broader applications.