For research use only. Not for therapeutic Use.
Eflornithine (Cat.No:I004627) is a medication used for the treatment of excessive facial hair growth in women (hirsutism). It works by inhibiting the enzyme ornithine decarboxylase, which is involved in hair follicle growth. Eflornithine slows down hair growth, resulting in reduced hair thickness and density.
| Catalog Number | I004627 |
| CAS Number | 70052-12-9 |
| Molecular Formula | C6H12F2N2O2 |
| Purity | ≥95% |
| Target | Parasite |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 2,5-diamino-2-(difluoromethyl)pentanoic acid |
| InChI | InChI=1S/C6H12F2N2O2/c7-4(8)6(10,5(11)12)2-1-3-9/h4H,1-3,9-10H2,(H,11,12) |
| InChIKey | VLCYCQAOQCDTCN-UHFFFAOYSA-N |
| SMILES | O=C(O)C(C(F)F)(N)CCCN |
| Reference | </br>1:Efficacy and safety of eflornithine (CPP-1X)/sulindac combination therapy versus each as monotherapy in patients with familial adenomatous polyposis (FAP): design and rationale of a randomized, double-blind, Phase III trial. Burke CA, Dekker E, Samadder NJ, Stoffel E, Cohen A.BMC Gastroenterol. 2016 Aug 2;16(1):87. doi: 10.1186/s12876-016-0494-4. PMID: 27480131 Free PMC Article</br>2:Adjuvant eflornithine to maintain IPL-induced hair reduction in women with facial hirsutism: a randomized controlled trial. Vissing AC, Taudorf EH, Haak CS, Philipsen PA, Haedersdal M.J Eur Acad Dermatol Venereol. 2016 Feb;30(2):314-9. doi: 10.1111/jdv.13447. Epub 2015 Oct 27. PMID: 26507926 </br>3:PACES trial: Evaluating the effectiveness of eflornithine and sulindac in preventing colon adenomas. Zell J, You YN, Boughey JC.Bull Am Coll Surg. 2015 Aug;100(8):70-1. No abstract available. PMID: 26419059 </br>4:Spectrophotometric estimation of eflornithine hydrochloride by using ion-pair reagents. Kumar A, Singh V, Kumar P.Pak J Pharm Sci. 2015 Mar;28(2):623-9. PMID: 25730793 </br>5:Enantiospecific reassessment of the pharmacokinetics and pharmacodynamics of oral eflornithine against late-stage Trypanosoma brucei gambiense sleeping sickness. Jansson-Löfmark R, Na-Bangchang K, Björkman S, Doua F, Ashton M.Antimicrob Agents Chemother. 2015 Feb;59(2):1299-307. doi: 10.1128/AAC.04101-14. Epub 2014 Dec 15. PMID: 25512417 Free PMC Article</br>6:A simple and sensitive assay for eflornithine quantification in rat brain using pre-column derivatization and UPLC-MS/MS detection. Yang S, Peng KW, Wang MZ.Biomed Chromatogr. 2015 Jun;29(6):918-24. doi: 10.1002/bmc.3374. Epub 2014 Nov 4. PMID: 25365958 </br>7:Eflornithine (DFMO) prevents progression of pancreatic cancer by modulating ornithine decarboxylase signaling. Mohammed A, Janakiram NB, Madka V, Ritchie RL, Brewer M, Biddick L, Patlolla JM, Sadeghi M, Lightfoot S, Steele VE, Rao CV.Cancer Prev Res (Phila). 2014 Dec;7(12):1198-209. doi: 10.1158/1940-6207.CAPR-14-0176. Epub 2014 Sep 23. PMID: 25248858 Free PMC Article</br>8:A method to improve the efficacy of topical eflornithine hydrochloride cream. Kumar A, Naguib YW, Shi YC, Cui Z.Drug Deliv. 2016 Jun;23(5):1495-501. doi: 10.3109/10717544.2014.951746. Epub 2014 Sep 3. PMID: 25182303 </br>9:Trypanosoma brucei eflornithine transporter AAT6 is a low-affinity low-selective transporter for neutral amino acids. Mathieu C, González Salgado A, Wirdnam C, Meier S, Grotemeyer MS, Inbar E, Mäser P, Zilberstein D, Sigel E, Bütikofer P, Rentsch D.Biochem J. 2014 Oct 1;463(1):9-18. doi: 10.1042/BJ20140719. PMID: 24988048 </br>10:DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma. Koomoa DL, Geerts D, Lange I, Koster J, Pegg AE, Feith DJ, Bachmann AS.Int J Oncol. 2013 Apr;42(4):1219-28. doi: 10.3892/ijo.2013.1835. Epub 2013 Feb 21. PMID: 23440295 Free PMC Article |
