EGFR-IN-5

• CAT Number: I019528
• CAS Number: 2225887-26-1
• Molecular Formula: C₃₁H₃₈FN₉O
• Molecular Weight: 571.69
• Purity: ≥95%

EGFR-IN-5 is a EGFR inhibitor with IC50s of 10.4, 1.1, 34, 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively.

Reference

[1]. Zhang H, et al. Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs. Eur J Med Chem. 2018 Mar 25;148:221-237.