For research use only. Not for therapeutic Use.
EGS Crosslinker（Cat No.:I014351）, also known as ethylene glycol bis(succinimidyl succinate), is a water-insoluble homobifunctional crosslinker commonly employed in biochemical studies. It is utilized to label intracellular proteins and investigate protein-protein or protein-DNA interactions. EGS Crosslinker is particularly useful in chromatin immunoprecipitation (ChIP) assays to study DNA-protein binding interactions. It forms stable covalent bonds between amino groups nearby, allowing for the capture and analysis of protein complexes.
| Catalog Number | I014351 |
| CAS Number | 70539-42-3 |
| Synonyms | EGS Crosslinker, EGS Cross linker;Ethylene Glycol-Bis (Succinic Acid N-Hydroxysuccinimide Ester) |
| Molecular Formula | C18H20N2O12 |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| Solubility | Soluble in DMSO |
| Storage | 2-8°C |
| IUPAC Name | 4-O-(2,5-dioxopyrrolidin-1-yl) 1-O-[2-[4-(2,5-dioxopyrrolidin-1-yl)oxy-4-oxobutanoyl]oxyethyl] butanedioate |
| InChI | InChI=1S/C18H20N2O12/c21-11-1-2-12(22)19(11)31-17(27)7-5-15(25)29-9-10-30-16(26)6-8-18(28)32-20-13(23)3-4-14(20)24/h1-10H2 |
| InChIKey | QLHLYJHNOCILIT-UHFFFAOYSA-N |
| SMILES | C1CC(=O)N(C1=O)OC(=O)CCC(=O)OCCOC(=O)CCC(=O)ON2C(=O)CCC2=O |
| Reference | </br>1: Dreiling A, Hanneken M, König S. Early cleavage of ethylene glycol bis(succinimidylsuccinate) (EGS)-linker moieties during enzymatic digestion of cross-linked proteins. Rapid Commun Mass Spectrom. 2014 Nov 15;28(21):2385-8. doi: 10.1002/rcm.7034. PubMed PMID: 25279753.</br>2: Lakra R, Kiran MS, Sai KP. Fabrication of homobifunctional crosslinker stabilized collagen for biomedical application. Biomed Mater. 2015 Nov 27;10(6):065015. doi: 10.1088/1748-6041/10/6/065015. PubMed PMID: 26610606. </br> </br> |
