For research use only, not for therapeutic use.
EIDD-1931 (Cat. No: I026767), an active metabolite of EIDD-2801, is a promising COVID-19 inhibitor. The average IC50 value of EIDD-1931 (NHC) against SAChemicalbookRS-CoV-2, MERS-CoV, SARS-CoV, and relatedzoonoticgroup2b or2cBat-CoVs was 0.15μM, and the efficacy of EIDD-1931 against coronavirus with resistance mutation to nucleoside analogue inhibitor Remdesivir was enhanced.
Catalog Number | I026767 |
CAS Number | 3258-02-4 |
Synonyms | EIDD-1931; EIDD 1931; EIDD1931; N4-Hydroxycytidine; β-D-N4-hydroxycytidine; Uridine, 4-oxime; NHC; EIDD-2801-metabolite; Molnupiravir-,etabolite |
Molecular Formula | C9H13N3O6 |
Purity | 98% |
Solubility | Soluble in DMSO |
Appearance | Solid powder |
Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
IUPAC Name | N4-Hydroxycytidine |
InChI | InChI=1S/C9H13N3O6/c13-3-4-6(14)7(15)8(18-4)12-2-1-5(11-17)10-9(12)16/h1-2,4,6-8,13-15,17H,3H2,(H,10,11,16)/t4-,6-,7-,8-/m1/s1 |
InChIKey | XCUAIINAJCDIPM-XVFCMESISA-N |
SMILES | OC[C@@H]1[C@H]([C@H]([C@H](N2C(N=C(C=C2)NO)=O)O1)O)O |
Reference | 1: Sheahan TP, Sims AC, Zhou S, Graham RL, Pruijssers AJ, Agostini ML, Leist SR, Schäfer A, Dinnon KH 3rd, Stevens LJ, Chappell JD, Lu X, Hughes TM, George AS, Hill CS, Montgomery SA, Brown AJ, Bluemling GR, Natchus MG, Saindane M, Kolykhalov AA, Painter G, Harcourt J, Tamin A, Thornburg NJ, Swanstrom R, Denison MR, Baric RS. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci Transl Med. 2020 Apr 6:eabb5883. doi: 10.1126/scitranslmed.abb5883. Epub ahead of print. PMID: 32253226. |