For research use only. Not for therapeutic Use.
EIDD-1931(Cat No.:I026767)is an antiviral compound primarily developed as an inhibitor of the SARS-CoV-2 virus, specifically targeting its RNA-dependent RNA polymerase (RdRp). It is the active metabolite of EIDD-2801 (molnupiravir), demonstrating potent antiviral activity against a range of RNA viruses. EIDD-1931 functions by introducing errors into the viral RNA, leading to viral mutagenesis and inhibition of viral replication. It has shown efficacy in preclinical models against coronaviruses and influenza, positioning it as a promising therapeutic candidate for treating viral infections, especially in pandemic scenarios.
Catalog Number | I026767 |
CAS Number | 3258-02-4 |
Synonyms | EIDD-1931; EIDD 1931; EIDD1931; N4-Hydroxycytidine; β-D-N4-hydroxycytidine; Uridine, 4-oxime; NHC; EIDD-2801-metabolite; Molnupiravir-,etabolite |
Molecular Formula | C9H13N3O6 |
Purity | 98% |
Target | Cell Cycle/DNA Damage |
Solubility | Soluble in DMSO |
Appearance | Solid powder |
Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
IUPAC Name | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one |
InChI | InChI=1S/C9H13N3O6/c13-3-4-6(14)7(15)8(18-4)12-2-1-5(11-17)10-9(12)16/h1-2,4,6-8,13-15,17H,3H2,(H,10,11,16)/t4-,6-,7-,8-/m1/s1 |
InChIKey | XCUAIINAJCDIPM-XVFCMESISA-N |
SMILES | C1=CN(C(=O)N=C1NO)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O |
Reference | 1: Sheahan TP, Sims AC, Zhou S, Graham RL, Pruijssers AJ, Agostini ML, Leist SR, Schäfer A, Dinnon KH 3rd, Stevens LJ, Chappell JD, Lu X, Hughes TM, George AS, Hill CS, Montgomery SA, Brown AJ, Bluemling GR, Natchus MG, Saindane M, Kolykhalov AA, Painter G, Harcourt J, Tamin A, Thornburg NJ, Swanstrom R, Denison MR, Baric RS. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci Transl Med. 2020 Apr 6:eabb5883. doi: 10.1126/scitranslmed.abb5883. Epub ahead of print. PMID: 32253226. |