eIF4A i28

• CAT Number: I047727
• CAS Number: 2861994-92-3
• Molecular Formula: C24H20N2O5
• Molecular Weight: 416.43
• Purity: ≥95%
• IUPAC Name: 2-[5-(4-butylphenyl)furan-2-yl]-6-nitroquinoline-4-carboxylic acid
• InChI: InChI=1S/C24H20N2O5/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(31-22)21-14-19(24(27)28)18-13-17(26(29)30)9-10-20(18)25-21/h5-14H,2-4H2,1H3,(H,27,28)
• SMILES: CCCCC1=CC=C(C=C1)C2=CC=C(O2)C3=NC4=C(C=C(C=C4)[N+](=O)[O-])C(=C3)C(=O)O

eIF4A i28 is a RNA-competitive, ATP-uncompetitive eIF4A inhibitor with an IC50 of 8.6 μM. eIF4A i28 binds a novel pocket in the RNA groove and inhibits eIF4A with a novel mechanism in which it perturbs RNA binding, blocks the hydrolysis of ATP, and consequently inhibits RNA helicase activity.
Keywords: eIF4A i28 | Supplier | eIF4A inhibitor | eIF4Ai28 | eIF4A-i28 | CAS [2861994-92-3] | DNA-RNA | Helicase-Primase | Inhibitor | Enzymes | ATP-powered DEAD-box RNA-helicase | Eukaryotic initiation factor (eIF)4A

Reference

CJ Zerio et al. Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action. J Med Chem. 2021 Nov 11;64(21):15727-15746.