For research use only. Not for therapeutic Use.
EIPA hydrochloride (Cat No.:I019130) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also inhibits the Na+/H+ exchanger (NHE) and macrophages. If you need, please contact us in time, and we will reply as soon as possible within 24 hours.
| Catalog Number | I019130 |
| CAS Number | 1345839-28-2 |
| Molecular Formula | C₁₁H₁₉Cl₂N₇O |
| Purity | ≥95% |
| Storage | Store at -20°C |
| IUPAC Name | 3-amino-6-chloro-N-(diaminomethylidene)-5-[ethyl(propan-2-yl)amino]pyrazine-2-carboxamide;hydrochloride |
| InChI | InChI=1S/C11H18ClN7O.ClH/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15;/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20);1H |
| InChIKey | BGHBOQNLQNKPFO-UHFFFAOYSA-N |
| SMILES | CCN(C1=NC(=C(N=C1Cl)C(=O)N=C(N)N)N)C(C)C.Cl |
| Reference | [1]. Dai XQ, et al. Inhibition of TRPP3 channel by MK-870 and analogs. Mol Pharmacol. 2007 Dec;72(6):1576-85.<br>[2]. Shi H, et al. Na+/H+ Exchanger Regulates Amino Acid-Mediated Autophagy in Intestinal Epithelial Cells. Cell Physiol Biochem. 2017;42(6):2418-2429.<br>[3]. Zhu BY, et al. A new HDAC inhibitor cinnamoylphenazine shows antitumor activity in association with intensive macropinocytosis. |
