ELA-11(human)

• CAT Number: I008551
• CAS Number: 1784687-32-6
• Molecular Formula: C58H90N16O13S2
• Molecular Weight: 1283.56
• Purity: ≥95%

ELA-11(human), a peptide, is a full agonist of human apelin receptor, with a pKi of 7.85. ELA-11(human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment[1].
ELA-11(human) (1 pM-100 nM) completely inhibits Forskolin-induced cAMP production in a concentration-dependent manner[1].
ELA-11(human) (1 pM-1 μM) stimulates β-arrestin recruitment in a concentration-dependent manner with subnanomolar potencies[1].

Reference

[1]. Yang P, et, al. Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension. Circulation. 2017 Mar 21;135(12):1160-1173.
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