For research use only. Not for therapeutic Use.
Elaiophylin(CAT: R001856) is a natural macrolide compound produced by certain Streptomyces bacteria. It has been a subject of scientific interest due to its diverse range of biological activities and potential pharmaceutical applications. Elaiophylin is known for its potent antiproliferative and cytotoxic effects, which make it a candidate for cancer research and treatment. It has been explored for its ability to inhibit protein synthesis and induce apoptosis in cancer cells. Additionally, elaiophylin exhibits antibiotic properties, suggesting its potential in combating bacterial infections.
Catalog Number | R001856 |
CAS Number | 37318-06-2 |
Synonyms | Azalomycin-B;Gopalamicin;Salbomycin |
Molecular Formula | C54H88O18 |
Purity | ≥95% |
Target | Anti-infection |
Storage | >95% by HPLC |
IUPAC Name | (3E,5E,7S,8S,11E,13E,15S,16S)-8,16-bis[(2S,3R,4S)-4-[(2R,4R,5R,6R)-4-[(2R,4S,5S,6S)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-5-ethyl-2-hydroxy-6-methyloxan-2-yl]-3-hydroxypentan-2-yl]-7,15-dimethyl-1,9-dioxacyclohexadeca-3,5,11,13-tetraene-2,10-dione |
InChI | InChI=1S/C54H88O18/c1-13-37-33(9)71-53(63,25-41(37)67-45-23-39(55)49(61)35(11)65-45)31(7)47(59)29(5)51-27(3)19-15-17-22-44(58)70-52(28(4)20-16-18-21-43(57)69-51)30(6)48(60)32(8)54(64)26-42(38(14-2)34(10)72-54)68-46-24-40(56)50(62)36(12)66-46/h15-22,27-42,45-52,55-56,59-64H,13-14,23-26H2,1-12H3/b19-15+,20-16+,21-18+,22-17+/t27-,28-,29-,30-,31-,32-,33+,34+,35-,36-,37+,38+,39-,40-,41+,42+,45-,46-,47+,48+,49+,50+,51-,52-,53+,54+/m0/s1 |
InChIKey | OSERMIPXNLXAPD-MJMYBOKFSA-N |
SMILES | CCC1C(OC(CC1OC2CC(C(C(O2)C)O)O)(C(C)C(C(C)C3C(C=CC=CC(=O)OC(C(C=CC=CC(=O)O3)C)C(C)C(C(C)C4(CC(C(C(O4)C)CC)OC5CC(C(C(O5)C)O)O)O)O)C)O)O)C |
Reference | Cation selective ion channels formed by macrodiolide antibiotic elaiophylin in lipid bilayer membranes. Grigoriev P.A. et al. Bioelectrochemistry 2001, 54, 11.<br/><br/>Enhancement of the antifungal activity of rapamycin by the coproduced elaiophylin and nigericin. Fang A. et al. J Antibiot. 2000, 53,158.</span></p> |