Elaiophylin

For research use only. Not for therapeutic Use.

  • CAT Number: R001856
  • CAS Number: 37318-06-2
  • Molecular Formula: C54H88O18
  • Molecular Weight: 1025.28
  • Purity: ≥95%
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Elaiophylin(CAT: R001856) is a natural macrolide compound produced by certain Streptomyces bacteria. It has been a subject of scientific interest due to its diverse range of biological activities and potential pharmaceutical applications. Elaiophylin is known for its potent antiproliferative and cytotoxic effects, which make it a candidate for cancer research and treatment. It has been explored for its ability to inhibit protein synthesis and induce apoptosis in cancer cells. Additionally, elaiophylin exhibits antibiotic properties, suggesting its potential in combating bacterial infections.


Catalog Number R001856
CAS Number 37318-06-2
Synonyms

Azalomycin-B;Gopalamicin;Salbomycin

Molecular Formula C54H88O18
Purity ≥95%
Target Anti-infection
Storage >95% by HPLC
IUPAC Name (3E,5E,7S,8S,11E,13E,15S,16S)-8,16-bis[(2S,3R,4S)-4-[(2R,4R,5R,6R)-4-[(2R,4S,5S,6S)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-5-ethyl-2-hydroxy-6-methyloxan-2-yl]-3-hydroxypentan-2-yl]-7,15-dimethyl-1,9-dioxacyclohexadeca-3,5,11,13-tetraene-2,10-dione
InChI InChI=1S/C54H88O18/c1-13-37-33(9)71-53(63,25-41(37)67-45-23-39(55)49(61)35(11)65-45)31(7)47(59)29(5)51-27(3)19-15-17-22-44(58)70-52(28(4)20-16-18-21-43(57)69-51)30(6)48(60)32(8)54(64)26-42(38(14-2)34(10)72-54)68-46-24-40(56)50(62)36(12)66-46/h15-22,27-42,45-52,55-56,59-64H,13-14,23-26H2,1-12H3/b19-15+,20-16+,21-18+,22-17+/t27-,28-,29-,30-,31-,32-,33+,34+,35-,36-,37+,38+,39-,40-,41+,42+,45-,46-,47+,48+,49+,50+,51-,52-,53+,54+/m0/s1
InChIKey OSERMIPXNLXAPD-MJMYBOKFSA-N
SMILES CCC1C(OC(CC1OC2CC(C(C(O2)C)O)O)(C(C)C(C(C)C3C(C=CC=CC(=O)OC(C(C=CC=CC(=O)O3)C)C(C)C(C(C)C4(CC(C(C(O4)C)CC)OC5CC(C(C(O5)C)O)O)O)O)C)O)O)C
Reference

Cation selective ion channels formed by macrodiolide antibiotic elaiophylin in lipid bilayer membranes. Grigoriev P.A. et al. Bioelectrochemistry 2001, 54, 11.<br/><br/>Enhancement of the antifungal activity of rapamycin by the coproduced elaiophylin and nigericin. Fang A. et al. J Antibiot. 2000, 53,158.</span></p>

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