For research use only. Not for therapeutic Use.
Elamipretide Triacetate (Cat No.: I040004) is a mitochondria-targeting peptide that enhances mitochondrial function by stabilizing cardiolipin, a crucial phospholipid in the inner mitochondrial membrane. It is widely studied for its potential in treating mitochondrial dysfunction-related diseases, including heart failure, neurodegenerative disorders, and rare mitochondrial diseases. By improving energy production and reducing oxidative stress, Elamipretide supports cellular health and function. The triacetate form enhances solubility and stability for in vitro and in vivo applications, making it valuable in drug development and therapeutic research.
| CAS Number | 1849610-71-4 |
| Synonyms | acetic acid;(2S)-6-amino-2-[[(2S)-2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]hexanamide |
| Molecular Formula | C38H61N9O11 |
| Purity | ≥95% |
| InChI | InChI=1S/C32H49N9O5.3C2H4O2/c1-19-15-22(42)16-20(2)23(19)18-27(41-29(44)24(34)11-8-14-38-32(36)37)31(46)39-25(12-6-7-13-33)30(45)40-26(28(35)43)17-21-9-4-3-5-10-21;3*1-2(3)4/h3-5,9-10,15-16,24-27,42H,6-8,11-14,17-18,33-34H2,1-2H3,(H2,35,43)(H,39,46)(H,40,45)(H,41,44)(H4,36,37,38);3*1H3,(H,3,4)/t24-,25+,26+,27+;;;/m1.../s1 |
| InChIKey | ZTOJICBVNLHTEQ-QTSNMJAOSA-N |
| SMILES | CC1=CC(=CC(=C1CC(C(=O)NC(CCCCN)C(=O)NC(CC2=CC=CC=C2)C(=O)N)NC(=O)C(CCCN=C(N)N)N)C)O.CC(=O)O.CC(=O)O.CC(=O)O |
| Reference | [1]. Zhao W, et al., Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice. J Neuroinflammation. 2019 Nov 20;16(1):230. [2]. Sabbah HN,et al., Chronic Therapy With Elamipretide (MTP-131), a Novel Mitochondria-Targeting Peptide, Improves Left Ventricular and Mitochondrial Function in Dogs With Advanced Heart Failure. Circ Heart Fail. 2016 Feb;9(2):e002206. |
