Elastase Inhibitor, SPCK

• CAT Number: I012083
• CAS Number: 65144-34-5
• Molecular Formula: C22H35ClN4O7
• Molecular Weight: 502.99
• Purity: ≥95%
• Synonyms: MeOSuc-Ala-Ala-Pro-Val-chloromethylketone; MeOSuc-AAPV-CMK
• Target: Elastase
• Solubility: DMSO
• Storage: -20°C
• IUPAC Name: methyl 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(3S)-1-chloro-4-methyl-2-oxopentan-3-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoate
• InChI: InChI=1S/C22H35ClN4O7/c1-12(2)19(16(28)11-23)26-21(32)15-7-6-10-27(15)22(33)14(4)25-20(31)13(3)24-17(29)8-9-18(30)34-5/h12-15,19H,6-11H2,1-5H3,(H,24,29)(H,25,31)(H,26,32)/t13-,14-,15-,19-/m0/s1
• InChIKey: PJGDFLJMBAYGGC-XLPNERPQSA-N
• SMILES: CC(C)C(C(=O)CCl)NC(=O)C1CCCN1C(=O)C(C)NC(=O)C(C)NC(=O)CCC(=O)OC

Elastase Inhibitor, SPCK (CAT: I012083) is a potent and irreversible inhibitor of elastase, a serine protease involved in degrading elastin and other proteins in the extracellular matrix. SPCK covalently binds to the active site of elastase, effectively blocking its activity. This compound is widely used in biochemistry and pharmaceutical research, particularly for studying protease-mediated tissue remodeling, inflammation, and diseases such as pulmonary emphysema, cystic fibrosis, and chronic inflammatory conditions. SPCK also aids in exploring therapeutic strategies to modulate elastase activity in pathological states, providing insights into enzyme inhibition and protease regulation.