Elastin

• CAT Number: I026783
• CAS Number: 9007-58-3
• Molecular Formula: C27H48N6O6
• Molecular Weight: 552.71
• Purity: 98%
• Synonyms: Elastin
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
• IUPAC Name: (S)-1-(acetyl-L-leucyl-L-isoleucylglycyl-L-valyl)-N-methylpyrrolidine-2-carboxamide
• InChI: InChI=1S/C27H48N6O6/c1-9-17(6)23(32-24(36)19(13-15(2)3)30-18(7)34)26(38)29-14-21(35)31-22(16(4)5)27(39)33-12-10-11-20(33)25(37)28-8/h15-17,19-20,22-23H,9-14H2,1-8H3,(H,28,37)(H,29,38)(H,30,34)(H,31,35)(H,32,36)/t17-,19-,20-,22-,23-/m0/s1
• InChIKey: DPUYCSDGMSDKKV-MKBYFEBXSA-N
• SMILES: CC[C@@H]([C@@H](C(NCC(N[C@H](C(N1CCC[C@H]1C(NC)=O)=O)C(C)C)=O)=O)NC([C@@H](NC(C)=O)CC(C)C)=O)C

Elastin (Cat.No:I026783) is a key protein of the extracellular matrix. It is highly elastic and present in connective tissue allowing many tissues in the body to resume their shape after stretching or contracting. Elastin helps skin to return to its original position when it is poked or pinched. Elastin is also an important load-bearing tissue in the bodies of vertebrates and used in places where mechanical energy is required to be stored. In humans, elastin is encoded by the ELN gene.

Reference

1: Cenaj O, Allison DHR, Imam R, Zeck B, Drohan LM, Chiriboga L, Llewellyn J, Liu CZ, Park YN, Wells RG, Theise ND. Evidence for continuity of interstitial spaces across tissue and organ boundaries in humans. Commun Biol. 2021 Mar 31;4(1):436. doi: 10.1038/s42003-021-01962-0. PMID: 33790388.
2: Gacek E, Bermel EA, Ellingson AM, Barocas VH. Through-thickness regional variation in the mechanical characteristics of the lumbar facet capsular ligament. Biomech Model Mechanobiol. 2021 Mar 31. doi: 10.1007/s10237-021-01455-3. Epub ahead of print. PMID: 33788068.
3: Munshaw S, Bruche S, Redpath AN, Jones A, Patel J, Dubé KN, Lee R, Hester SS, Davies R, Neal G, Handa A, Sattler M, Fischer R, Channon KM, Smart N. Thymosin β4 protects against aortic aneurysm via endocytic regulation of growth factor signaling. J Clin Invest. 2021 Mar 30:127884. doi: 10.1172/JCI127884. Epub ahead of print. PMID: 33784254.
4: Zhang M, Huang Y, Wu Q, Lin T, Gong X, Chen H, Wang Y. Comparison of 1064-nm and Dual-Wavelength (532/1064-nm) Picosecond-Domain Nd:YAG Lasers in the Treatment of Facial Photoaging: A Randomized Controlled Split-Face Study. Lasers Surg Med. 2021 Mar 30. doi: 10.1002/lsm.23404. Epub ahead of print. PMID: 33783878.
5: Kang HJ, Kumar S, D’Elia A, Dash B, Nanda V, Hsia HC, Yarmush ML, Berthiaume F. Self-assembled elastin-like polypeptide fusion protein coacervates as competitive inhibitors of advanced glycation end-products enhance diabetic wound healing. J Control Release. 2021 Mar 26:S0168-3659(21)00143-7. doi: 10.1016/j.jconrel.2021.03.032. Epub ahead of print. PMID: 33781808.
6: Chen JY, Wu YP, Li CY, Jheng HF, Kao LZ, Yang CC, Leu SY, Lien IC, Weng WT, Tai HC, Chiou YW, Tang MJ, Tsai PJ, Tsai YS. PPARγ activation improves the microenvironment of perivascular adipose tissue and attenuates aortic stiffening in obesity. J Biomed Sci. 2021 Mar 29;28(1):22. doi: 10.1186/s12929-021-00720-y. PMID: 33781257.
7: Koba T, Takeda Y, Narumi R, Shiromizu T, Nojima Y, Ito M, Kuroyama M, Futami Y, Takimoto T, Matsuki T, Edahiro R, Nojima S, Hayama Y, Fukushima K, Hirata H, Koyama S, Iwahori K, Nagatomo I, Suzuki M, Shirai Y, Murakami T, Nakanishi K, Nakatani T, Suga Y, Miyake K, Shiroyama T, Kida H, Sasaki T, Ueda K, Mizuguchi K, Adachi J, Tomonaga T, Kumanogoh A. Proteomics of serum extracellular vesicles identifies a novel COPD biomarker, fibulin-3 from elastic fibres. ERJ Open Res. 2021 Mar 22;7(1):00658-2020. doi: 10.1183/23120541.00658-2020. PMID: 33778046; PMCID: PMC7983195.
8: Moreno J, Escobedo D, Calhoun C, Le Saux CJ, Han HC. Arterial Wall Stiffening in Caveolin-1 Deficiency-Induced Pulmonary Artery Hypertension in Mice. Exp Mech. 2021 Jan;6(1):217-228. doi: 10.1007/s11340-020-00666-6. Epub 2020 Oct 14. PMID: 33776068; PMCID: PMC7993546.
9: Dahal S, Kuang M, Rietsch A, Butler RS, Ramamurthi A, Damaser MS. Quantitative Morphometry of Elastic Fibers in Pelvic Organ Prolapse. Ann Biomed Eng. 2021 Mar 23. doi: 10.1007/s10439-021-02760-9. Epub ahead of print. PMID: 33768411.
10: Schellinger IN, Wagenhäuser M, Chodisetti G, Mattern K, Dannert A, Petzold A, Jakubizka-Smorag J, Emrich F, Haunschild J, Schuster A, Schwob E, Schulz K, Maegdefessel L, Spin JM, Stumvoll M, Hasenfuß G, Tsao PS, Raaz U. MicroRNA miR-29b regulates diabetic aortic remodeling and stiffening. Mol Ther Nucleic Acids. 2021 Feb 24;24:188-199. doi: 10.1016/j.omtn.2021.02.021. PMID: 33767915; PMCID: PMC7957025.
11: Collettini F, Reimann C, Brangsch J, Chapiro J, Savic LJ, Onthank DC, Robinson SP, Karst U, Buchholz R, Keller S, Hamm B, Goldberg SN, Makowski MR. Elastin-specific MRI of extracellular matrix-remodelling following hepatic radiofrequency-ablation in a VX2 liver tumor model. Sci Rep. 2021 Mar 25;11(1):6814. doi: 10.1038/s41598-021-86417-6. PMID: 33767303; PMCID: PMC7994448.
12: Chowdhury A, Nosoudi N, Karamched S, Parasaram V, Vyavahare N. Polyphenol treatments increase elastin and collagen deposition by human dermal fibroblasts; Implications to improve skin health. J Dermatol Sci. 2021 Mar 16:S0923-1811(21)00050-5. doi: 10.1016/j.jdermsci.2021.03.002. Epub ahead of print. PMID: 33766446.
13: Ren K, Li B, Liu Z, Xia L, Zhai M, Wei X, Duan W, Yu S. GDF11 prevents the formation of thoracic aortic dissection in mice: Promotion of contractile transition of aortic SMCs. J Cell Mol Med. 2021 Mar 25. doi: 10.1111/jcmm.16312. Epub ahead of print. PMID: 33764670.
14: Liang K, Cui M, Fu X, Ma J, Zhang K, Zhang D, Zhai S. LncRNA Xist induces arterial smooth muscle cell apoptosis in thoracic aortic aneurysm through miR-29b-3p/Eln pathway. Biomed Pharmacother. 2021 May;137:111163. doi: 10.1016/j.biopha.2020.111163. Epub 2021 Feb 22. PMID: 33761588.
15: Bocquet O, Wahart A, Sarazin T, Vincent E, Schneider C, Fougerat A, Gayral S, Henry A, Blaise S, Romier-Crouzet B, Boulagnon C, Jaisson S, Gillery PP, Bennasroune A, Sartelet H, Laffargue M, Martiny PL, Duca PL, Maurice P. Adverse effects of oseltamivir phosphate therapy on the liver of LDLR-/- mice without any benefit on atherosclerosis and thrombosis. J Cardiovasc Pharmacol. 2021 Feb 25. doi: 10.1097/FJC.0000000000001002. Epub ahead of print. PMID: 33760798.
16: Orozco-Hidalgo MT, Charrier M, Tjahjono N, Tesoriero RF Jr, Li D, Molinari S, Ryan KR, Ashby PD, Rad B, Ajo-Franklin CM. Engineering High-Yield Biopolymer Secretion Creates an Extracellular Protein Matrix for Living Materials. mSystems. 2021 Mar 23;6(2):e00903-20. doi: 10.1128/mSystems.00903-20. PMID: 33758029.
17: Bodkin AJ, Criswell SL. Hidradenitis suppurativa lesions are associated with decreased collagen, decreased elastin, and increased neovascularization. J Histotechnol. 2021 Mar 24:1-10. doi: 10.1080/01478885.2020.1861924. Epub ahead of print. PMID: 33757414.
18: Zhou C, Lin Z, Cao H, Chen Y, Li J, Zhuang X, Ma D, Ji L, Li W, Xu S, Pan B, Zheng L. Anxa1 in smooth muscle cells protects against acute aortic dissection. Cardiovasc Res. 2021 Mar 23:cvab109. doi: 10.1093/cvr/cvab109. Epub ahead of print. PMID: 33757117.
19: Shivji S, Kak I, Reid SL, Muir J, Hafezi-Bakhtiari S, Li-Chang H, Deliallisi A, Newell KJ, Grin A, Conner J, Kirsch R. Feasibility and Performance of Elastin Trichrome as a Primary Stain in Colorectal Cancer Resection Specimens: Results of an Interobserver Variability Study. Am J Surg Pathol. 2021 Mar 24. doi: 10.1097/PAS.0000000000001707. Epub ahead of print. PMID: 33756495.
20: Damanik FFR, Verkoelen N, van Blitterswijk C, Rotmans J, Moroni L. Control Delivery of Multiple Growth Factors to Actively Steer Differentiation and Extracellular Matrix Protein Production. Adv Biol (Weinh). 2021 Mar 22:e2000205. doi: 10.1002/adbi.202000205. Epub ahead of print. PMID: 33751850.