Eleclazine hydrochloride

• CAT Number: I001737
• CAS Number: 1448754-43-5
• Molecular Formula: C21H17ClF3N3O3
• Molecular Weight: 451.83
• Purity: ≥95%
• Target: Sodium Channel
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C

Eleclazine hydrochloride(CAT: I001737) is a novel inhibitor of the late sodium (Na+) current. It exerts its pharmacological action by selectively blocking the late inward sodium current in cardiac cells. By inhibiting this current, eleclazine hydrochloride helps to normalize and regulate the electrical activity of the heart. It is primarily used for the treatment of cardiac arrhythmias, particularly ventricular arrhythmias associated with conditions such as long QT syndrome and heart failure.

Reference

[1]. Rajamani S et al. The novel late Na+ current inhibitor, GS-6615 (eleclazine) and its anti-arrhythmic effects in rabbit isolated heart preparations. Br J Pharmacol. 2016 Jul 23.

[2]. Justo F et al. Inhibition of the cardiac late sodium current with eleclazine protects against ischemia-induced vulnerability to atrial fibrillation and reduces atrial and ventricular repolarization abnormalities in the absence and presence of concurrent adrenergic stimulation. Heart Rhythm. 2016 Sep;13(9):1860-7.