For research use only. Not for therapeutic Use.
Elevenostat (JB3-22) is a selective HDAC11 inhibitor (IC50=0.235 µM). Anti-multiple myeloma (MM) activity[1].
| Catalog Number | I043991 |
| CAS Number | 1454902-97-6 |
| Synonyms | N-hydroxy-4-[[(2-methoxyphenyl)carbamoylamino]methyl]benzamide |
| Molecular Formula | C16H17N3O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H17N3O4/c1-23-14-5-3-2-4-13(14)18-16(21)17-10-11-6-8-12(9-7-11)15(20)19-22/h2-9,22H,10H2,1H3,(H,19,20)(H2,17,18,21) |
| InChIKey | DZHNFBYCLJKJID-UHFFFAOYSA-N |
| SMILES | COC1=CC=CC=C1NC(=O)NCC2=CC=C(C=C2)C(=O)NO |
| Reference | [1]. Huang J, et al. Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function. Sci Rep. 2017;7(1):8626. Published 2017 Aug 17. [2]. Mostofa A, et al. Plasma cell dependence on histone/protein deacetylase 11 reveals a therapeutic target in multiple myeloma. JCI Insight. 2021;6(24):e151713. Published 2021 Dec 22. |
