For research use only. Not for therapeutic Use.
Elobixibat, also known as AZD-7806, AJG-533 and A 3309, is an IBAT inhibitor under development for the treatment of chronic constipation and irritable bowel syndrome with constipation (IBS-C). It works by blocking the enterohepatic circulation of bile acids, increasing the bile acid concentration in the gut, which accelerates intestinal passage and softens the stool.
| CAS Number | 439087-18-0 |
| Synonyms | (2R)-N-[2-[[3,3-Dibutyl-2,3,4,5-tetrahydro-7-(methylthio)-1,1-dioxido-5-phenyl-1,5-benzothiazepin-8-yl]oxy]acetyl]-2-phenylglycylglycine; |
| Molecular Formula | C36H45N3O7S2 |
| Purity | ≥95% |
| Target | Immunology/Inflammation |
| Storage | -20°C |
| IUPAC Name | 2-[[(2R)-2-[[2-[(3,3-dibutyl-7-methylsulfanyl-1,1-dioxo-5-phenyl-2,4-dihydro-1$l^{6} |
| InChI | InChI=1S/C36H45N3O7S2/c1-4-6-18-36(19-7-5-2)24-39(27-16-12-9-13-17-27)28-20-30(47-3)29(21-31(28)48(44,45)25-36)46-23-32(40)38-34(26-14-10-8-11-15-26)35(43)37-22-33(41)42/h8-17,20-21,34H,4-7,18-19,22-25H2,1-3H3,(H,37,43)(H,38,40)(H,41,42)/t34-/m1/s1 |
| InChIKey | XFLQIRAKKLNXRQ-UUWRZZSWSA-N |
| SMILES | CCCCC1(CN(C2=CC(=C(C=C2S(=O)(=O)C1)OCC(=O)NC(C3=CC=CC=C3)C(=O)NCC(=O)O)SC)C4=CC=CC=C4)CCCC |
| Reference | </br>1:Elobixibat and its potential role in chronic idiopathic constipation. Acosta A, Camilleri M.Therap Adv Gastroenterol. 2014 Jul;7(4):167-75. doi: 10.1177/1756283X14528269. Review. PMID: 25057297 Free PMC Article</br>2:Elobixibat for the treatment of constipation. Wong BS, Camilleri M.Expert Opin Investig Drugs. 2013 Feb;22(2):277-84. doi: 10.1517/13543784.2013.753056. Epub 2012 Dec 8. Review. PMID: 23215781 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
