ELOVL6-IN-4

• CAT Number: I041090
• CAS Number: 1170321-92-2
• Molecular Formula: C20H20F3N3O3S
• Molecular Weight: 439.45
• Purity: ≥95%
• Synonyms: (1S,5R)-3-pyridin-2-ylsulfonyl-N-[4-(trifluoromethyl)phenyl]-8-azabicyclo[3.2.1]octane-8-carboxamide
• InChI: InChI=1S/C20H20F3N3O3S/c21-20(22,23)13-4-6-14(7-5-13)25-19(27)26-15-8-9-16(26)12-17(11-15)30(28,29)18-3-1-2-10-24-18/h1-7,10,15-17H,8-9,11-12H2,(H,25,27)/t15-,16+,17?
• InChIKey: WYCGDOXAJCYGEC-SJPCQFCGSA-N
• SMILES: C1CC2CC(CC1N2C(=O)NC3=CC=C(C=C3)C(F)(F)F)S(=O)(=O)C4=CC=CC=N4

ELOVL6-IN-4 (Cat No.: I041090) is a selective small-molecule inhibitor of ELOVL6 (elongation of very long-chain fatty acids protein 6), an enzyme involved in the elongation of saturated and monounsaturated fatty acids. By inhibiting ELOVL6, this compound modulates lipid metabolism, making it valuable for studying metabolic disorders, insulin resistance, and non-alcoholic fatty liver disease (NAFLD). ELOVL6-IN-4 supports investigations into the regulation of fatty acid homeostasis and its impact on metabolic health. For research use only in preclinical and biochemical studies.

Reference

[1]. Tsuyoshi Nagase, et al. Synthesis and biological evaluation of a novel 3-sulfonyl-8-azabicyclo[3.2.1]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors. J Med Chem. 2009 Jul 23;52(14):4111-4.
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