For research use only. Not for therapeutic Use.
ELOVL6-IN-4 is a potent, selective, and orally active long chain fatty acid elongase 6 (ELOVL6) inhibitor with IC50s of 79 nM and 94 nM for human and mouse ELOVL6, respectively. ELOVL6-IN-4 shows excellent selectivity over the other human ELOVL subtypes (ELOVL1, -2, -3, and -5) and mouse ELOVL3[1].
ELOVL6-IN-4 (compound 1w) potently reduced the elongation index in mouse hepatocyte cells H2.35, with an IC50 of 30 nM.
ELOVL6-IN-4 (compound 1w; 1-10 mg/kg; oral administration; once) potently and dose-dependently suppresses the elongation index in the liver in mice[1].
| Catalog Number | I041090 |
| CAS Number | 1170321-92-2 |
| Synonyms | (1S,5R)-3-pyridin-2-ylsulfonyl-N-[4-(trifluoromethyl)phenyl]-8-azabicyclo[3.2.1]octane-8-carboxamide |
| Molecular Formula | C20H20F3N3O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C20H20F3N3O3S/c21-20(22,23)13-4-6-14(7-5-13)25-19(27)26-15-8-9-16(26)12-17(11-15)30(28,29)18-3-1-2-10-24-18/h1-7,10,15-17H,8-9,11-12H2,(H,25,27)/t15-,16+,17? |
| InChIKey | WYCGDOXAJCYGEC-SJPCQFCGSA-N |
| SMILES | C1CC2CC(CC1N2C(=O)NC3=CC=C(C=C3)C(F)(F)F)S(=O)(=O)C4=CC=CC=N4 |
| Reference | [1]. Tsuyoshi Nagase, et al. Synthesis and biological evaluation of a novel 3-sulfonyl-8-azabicyclo[3.2.1]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors. J Med Chem. 2009 Jul 23;52(14):4111-4. |
