ELR-510444

• CAT Number: I000924
• CAS Number: 1233948-35-0
• Molecular Formula: C₁₉H₁₆N₂O₂S₂
• Molecular Weight: 368.50
• Purity: ≥95%
• Synonyms: N-(5-(5-cyanothiophen-2-yl)-2-methylphenyl)-4-methylbenzenesulfonamide
• Target: Microtubule/Tubulin
• Solubility: DMSO: ≥ 37 mg/mL
• Storage: Store at -20°C
• IC50: 30.9 nM(MDA-MB-231 cell)
• IUPAC Name: N-[5-(5-cyanothiophen-2-yl)-2-methylphenyl]-4-methylbenzenesulfonamide
• InChI: InChI=1S/C19H16N2O2S2/c1-13-3-8-17(9-4-13)25(22,23)21-18-11-15(6-5-14(18)2)19-10-7-16(12-20)24-19/h3-11,21H,1-2H3
• InChIKey: GRYXROIHHXHFND-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C=CC(=C2)C3=CC=C(S3)C#N)C

ELR-510444（Cat No.:I000924）is a selective inhibitor targeting the soluble epoxide hydrolase (sEH) enzyme, known for its role in regulating inflammation and vascular tone. By inhibiting sEH, ELR-510444 increases the levels of anti-inflammatory and vasodilatory epoxyeicosatrienoic acids (EETs), making it a promising compound for cardiovascular and inflammatory disease research. This compound is valuable for exploring therapeutic strategies to treat hypertension, ischemia, and other vascular-related conditions. It is commonly used in pharmaceutical and biomedical research to investigate novel treatments for chronic inflammation and cardiovascular disorders.

Reference

1:ELR510444 inhibits tumor growth and angiogenesis by abrogating HIF activity and disrupting microtubules in renal cell carcinoma. Carew JS, Esquivel JA 2nd, Espitia CM, Schultes CM, Mülbaier M, Lewis JD, Janssen B, Giles FJ, Nawrocki ST.PLoS One. 2012;7(1):e31120. doi: 10.1371/journal.pone.0031120. Epub 2012 Jan 25. PMID: 22295124 Free PMC Article2:ELR510444, a novel microtubule disruptor with multiple mechanisms of action. Risinger AL, Westbrook CD, Encinas A, Mülbaier M, Schultes CM, Wawro S, Lewis JD, Janssen B, Giles FJ, Mooberry SL.J Pharmacol Exp Ther. 2011 Mar;336(3):652-60. doi: 10.1124/jpet.110.175331. Epub 2010 Dec 9. PMID: 21148249 Free PMC Article