Eltanexor

• CAT Number: I026800
• CAS Number: 1642300-52-4
• Molecular Formula: C17H10F6N6O
• Molecular Weight: 428.30
• Purity: 98%
• Synonyms: KPT-8602; KPT8602; KPT 8602. Eltanexor.
• Target: CRM1
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃for long term (months to years).
• IUPAC Name: (2E)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)prop-2-enamide
• InChI: InChI=1S/C17H10F6N6O/c18-16(19,20)11-1-9(2-12(3-11)17(21,22)23)15-27-8-29(28-15)6-13(14(24)30)10-4-25-7-26-5-10/h1-8H,(H2,24,30)/b13-6+
• InChIKey: JFBAVWVBLRIWHM-AWNIVKPZSA-N
• SMILES: O=C(N)/C(C1=CN=CN=C1)=C/N2N=C(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)N=C2

Eltanexor(CAT: I026800) referred to as KPT-8602, represents a significant advancement in the field of targeted therapies for hematological malignancies. As a second-generation exportin-1 inhibitor, Eltanexor disrupts the nuclear export of various proteins, influencing critical cellular processes. This compound has demonstrated potent activity against acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), targeting not only leukemia blasts but also leukemia-initiating cells.