For research use only. Not for therapeutic Use.
Eltoprazine (DU 28853) hydrochloride is a 5-HT1A/5-HT1B receptors agonist and a 5-HT2C receptor antagonist. Eltoprazine hydrochloride shows antiaggressive and anxiogenic effects[1][2].
Rats are chronically treated with Mianserin (10 mg/kg i.p.) or Eltoprazine (1 mg/kg i.p.) and are tested in the elevated plus-maze test for anxiety. Mianserin and Eltoprazine display opposite effects in the elevated plus-maze: Mianserin induces anxiolytic-like effects, while Eltoprazine shows anxiogenic-like ones[2].
| Catalog Number | I006647 |
| CAS Number | 98206-09-8 |
| Synonyms | 1-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazine;hydrochloride |
| Molecular Formula | C12H17ClN2O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C12H16N2O2.ClH/c1-2-10(14-6-4-13-5-7-14)12-11(3-1)15-8-9-16-12;/h1-3,13H,4-9H2;1H |
| InChIKey | JFSOSUNPIXJCIX-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1)C2=C3C(=CC=C2)OCCO3.Cl |
| Reference | [1]. Sijbesma H, et al. Eltoprazine, a drug which reduces aggressive behaviour, binds selectively to 5-HT1 receptor sites in the rat brain: an autoradiographic study. Eur J Pharmacol. 1990 Feb 20;177(1-2):55-66. [2]. Rocha B, et al. Chronic mianserin or eltoprazine treatment in rats: effects on the elevated plus-maze test and on limbic 5-HT2C receptor levels. Eur J Pharmacol. 1994 Sep 1;262(1-2):125-31. |
