Eluxadoline

• CAT Number: R036577
• CAS Number: 864821-90-9
• Molecular Formula: C32H35N5O5
• Molecular Weight: 569.70
• Purity: ≥95%
• Synonyms: 5-[[[(2S)-2-Amino-3-[4-(aminocarbonyl)-2,6-dimethylphenyl]-1-oxopropyl][(1S)-1-(5-phenyl-1H-imidazol-2-yl)ethyl]amino]methyl]-2-methoxybenzoic Acid; JNJ 27018966; Viberzi
• Target: opioid receptor antagonist
• Storage: -20°C
• IUPAC Name: 5-[[[(2S)-2-amino-3-(4-carbamoyl-2,6-dimethylphenyl)propanoyl]-[(1S)-1-(5-phenyl-1H-imidazol-2-yl)ethyl]amino]methyl]-2-methoxybenzoic acid
• InChI: InChI=1S/C32H35N5O5/c1-18-12-23(29(34)38)13-19(2)24(18)15-26(33)31(39)37(17-21-10-11-28(42-4)25(14-21)32(40)41)20(3)30-35-16-27(36-30)22-8-6-5-7-9-22/h5-14,16,20,26H,15,17,33H2,1-4H3,(H2,34,38)(H,35,36)(H,40,41)/t20-,26-/m0/s1
• InChIKey: QFNHIDANIVGXPE-FNZWTVRRSA-N
• SMILES: CC1=CC(=CC(=C1CC(C(=O)N(CC2=CC(=C(C=C2)OC)C(=O)O)C(C)C3=NC=C(N3)C4=CC=CC=C4)N)C)C(=O)N

Eluxadoline（Cat No.:R036577）is a mixed μ-opioid receptor agonist, κ-opioid receptor agonist, and δ-opioid receptor antagonist used primarily for treating irritable bowel syndrome with diarrhea (IBS-D). By modulating opioid receptors in the gastrointestinal tract, it reduces bowel contractions, alleviating abdominal pain and diarrhea without significant central nervous system effects. Its unique mechanism targets local gut receptors, offering symptom relief while minimizing constipation and systemic side effects. Eluxadoline’s efficacy and safety make it a preferred choice for IBS-D management, providing patients with improved quality of life through effective symptom control.