For research use only. Not for therapeutic Use.
EMAC10101d is a potent and selective toward hCA II inhibitor, with a Ki of 8.1 nM[1].
EMAC10101d exhibits Ki values of 9627.4 nM, 8.1 nM, 224.6 nM and 154.9 nM for hCA Ⅰ, hCA II, hCAⅨ and hCA Ⅻ, respectively[1].
| Catalog Number | I026809 |
| CAS Number | 2561476-24-0 |
| Synonyms | 4-[[4-(2,4-dichlorophenyl)-3-ethyl-1,3-thiazol-2-ylidene]amino]benzenesulfonamide |
| Molecular Formula | C17H15Cl2N3O2S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H15Cl2N3O2S2/c1-2-22-16(14-8-3-11(18)9-15(14)19)10-25-17(22)21-12-4-6-13(7-5-12)26(20,23)24/h3-10H,2H2,1H3,(H2,20,23,24) |
| InChIKey | OEGLVUQKHJHUEU-UHFFFAOYSA-N |
| SMILES | CCN1C(=CSC1=NC2=CC=C(C=C2)S(=O)(=O)N)C3=C(C=C(C=C3)Cl)Cl |
| Reference | [1]. Rita Meleddu, et al. New Dihydrothiazole Benzensulfonamides: Looking for Selectivity toward Carbonic Anhydrase Isoforms I, II, IX, and XII. ACS Med Chem Lett. 2020 Feb 13;11(5):852-856. |
