For research use only. Not for therapeutic Use.
Embelin (CAT: I004037) is a cell-permeable benzoquinone compound with notable antitumor properties. It exerts its effects by acting as an antagonist to XIAP (X-linked inhibitor of apoptosis protein), a protein that inhibits the activation of caspase-9. Embelin directly targets the Smac (second mitochondria-derived activator of caspases) and caspase-9 binding domain BIR3, thereby preventing XIAP from inhibiting caspase-9 activation. By doing so, embelin promotes caspase-9-mediated apoptosis, which is a critical mechanism for eliminating cancer cells. The ability of embelin to interfere with XIAP-mediated apoptosis inhibition highlights its potential as an anticancer therapeutic agent.
| Catalog Number | I004037 |
| CAS Number | 550-24-3 |
| Synonyms | 2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione |
| Molecular Formula | C17H26O4 |
| Purity | ≥95% |
| Target | IAP |
| Solubility | DMSO 10 mg/ml |
| Storage | 3 years -20C powder |
| IC50 | 4.1 uM [1] |
| InChIKey | IRSFLDGTOHBADP-UHFFFAOYSA-N |
| Reference | </br>1:Anti-plasmodial and Chloroquine Resistance Suppressive Effects of Embelin. Zaid OI, Majid RA, Hasidah MS, Sabariah MN, Al-Zihiry K, Rahi S, Basir R.Pharmacogn Mag. 2017 Jan;13(Suppl 1):S48-S55. doi: 10.4103/0973-1296.203982. Epub 2017 Apr 7. PMID: 28479726 Free PMC Article</br>2:Antipsychotic activity of embelin isolated from Embelia ribes: A preliminary study. Durg S, B NK, Vandal R, Dhadde SB, Thippeswamy BS, Veerapur VP, Badami S.Biomed Pharmacother. 2017 Jun;90:328-331. doi: 10.1016/j.biopha.2017.03.085. Epub 2017 Apr 1. PMID: 28376400 </br>3:ROS-mediated induction of apoptosis by benzoquinone embelin in human colon adenocarcinoma cells HT-29. Sumalatha K, Gowda M, Meenakshisundaram S.J Complement Integr Med. 2017 Mar 17. pii: /j/jcim.ahead-of-print/jcim-2016-0131/jcim-2016-0131.xml. doi: 10.1515/jcim-2016-0131. [Epub ahead of print] PMID: 28306533 </br>4:Plant Derived Phytocompound, Embelin in CNS Disorders: A Systematic Review. Kundap UP, Bhuvanendran S, Kumari Y, Othman I, Shaikh MF.Front Pharmacol. 2017 Feb 27;8:76. doi: 10.3389/fphar.2017.00076. eCollection 2017. Review. PMID: 28289385 Free PMC Article</br>5:Embelin attenuates adipogenesis and lipogenesis through activating canonical Wnt signaling and inhibits high-fat diet-induced obesity. Gao Y, Li J, Xu X, Wang S, Yang Y, Zhou J, Zhang L, Zheng F, Li X, Wang B.Int J Obes (Lond). 2017 May;41(5):729-738. doi: 10.1038/ijo.2017.35. Epub 2017 Feb 6. PMID: 28163317 </br>6:Chemical and biological aspects of the natural 1,4-benzoquinone embelin and its (semi-)synthetic derivatives. Shuveksh PS, Padhye S, Schobert R, Biersack B.Curr Med Chem. 2017 Jan 16. [Epub ahead of print] PMID: 28093981 </br>7:Antidiabetic activity of Embelia ribes, embelin and its derivatives: A systematic review and meta-analysis. Durg S, Veerapur VP, Neelima S, Dhadde SB.Biomed Pharmacother. 2017 Feb;86:195-204. doi: 10.1016/j.biopha.2016.12.001. Epub 2016 Dec 13. Review. PMID: 27984799 </br>8:Embelin supplementation of in vitro maturation medium does not influence nuclear and cytoplasmic maturation of pig oocytes. Galeati G, Giaretta E, Zannoni A, Bucci D, Tamanini C, Forni M, Spinaci M.J Physiol Pharmacol. 2016 Aug;67(4):513-519. PMID: 27779472 Free Article</br>9:Embelin Attenuates Intracerebroventricular Streptozotocin-Induced Behavioral, Biochemical, and Neurochemical Abnormalities in Rats. Arora R, Deshmukh R.Mol Neurobiol. 2016 Oct 15. [Epub ahead of print] PMID: 27744573 </br>10:Microwave-Assisted Organocatalytic Intramolecular Knoevenagel/Hetero Diels-Alder Reaction with O-(Arylpropynyloxy)-Salicylaldehydes: Synthesis of Polycyclic Embelin Derivatives. Martín-Acosta P, Feresin G, Tapia A, Estévez-Braun A.J Org Chem. 2016 Oct 21;81(20):9738-9756. Epub 2016 Oct 6. PMID: 27680299 |
