Emd 52297

• CAT Number: I026816
• CAS Number: 129049-51-0
• Molecular Formula: C39H59N11O7
• Molecular Weight: 793.97
• Purity: 98%
• Synonyms: Emd 52297; Emd-52297; Emd52297
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: tert-butyl (12-((1H-imidazol-5-yl)methyl)-4-(sec-butyl)-9-(cyclohexylmethyl)-8-hydroxy-3,6,11,14-tetraoxo-16-phenyl-1-(2H-tetrazol-2-yl)-2,5,10,13-tetraazahexadecan-15-yl)carbamate
• InChI: 1S/C39H59N11O7/c1-6-25(2)34(37(55)42-24-50-44-23-43-49-50)48-33(52)20-32(51)29(17-26-13-9-7-10-14-26)45-36(54)31(19-28-21-40-22-41-28)46-35(53)30(18-27-15-11-8-12-16-27)47-38(56)57-39(3,4)5/h8,11-12,15-16,21-23,25-26,29-32,34,51H,6-7,9-10,13-14,17-20,24H2,1-5H3,(H,40,41)(H,42,55)(H,45,54)(H,46,53)(H,47,56)(H,48,52)
• InChIKey: LXFRBEWNYDBACO-UHFFFAOYSA-N
• SMILES: CCC(C(NC(CC(O)C(NC(C(NC(C(NC(OC(C)(C)C)=O)Cc1ccccc1)=O)Cc2[nH]cnc2)=O)CC3CCCCC3)=O)C(NCn4nncn4)=O)C

EMD 52297(CAT: I026816) is a potent and selective renin inhibitor that targets the renin-angiotensin-aldosterone system (RAAS), a critical pathway in regulating blood pressure and fluid balance. By inhibiting renin, the enzyme responsible for converting angiotensinogen to angiotensin I, EMD 52297 effectively reduces the production of angiotensin II, a potent vasoconstrictor. This mechanism leads to vasodilation, decreased aldosterone secretion, and lowered blood pressure, making EMD 52297 a valuable candidate for the treatment of hypertension and other cardiovascular diseases. It is widely used in cardiovascular research to explore RAAS modulation and the development of novel antihypertensive therapies.