EMD57439

• CAT Number: I012657
• CAS Number: 148714-88-9
• Molecular Formula: C22H23N3O4S
• Molecular Weight: 425.50
• Purity: ≥95%
• Synonyms: EMD-57439; (-)-5-[1-(3,4-dimethoxybenzoyl)-1,2,3,4-tetrahydro-6-quinolyl]-6-methyl-3,6-dihydro-2H-1,3,4-thiadiazin-2-one
• IUPAC Name: (6S)-5-[1-(3,4-dimethoxybenzoyl)-3,4-dihydro-2H-quinolin-6-yl]-6-methyl-3,6-dihydro-1,3,4-thiadiazin-2-one
• InChI: InChI=1S/C22H23N3O4S/c1-13-20(23-24-22(27)30-13)15-6-8-17-14(11-15)5-4-10-25(17)21(26)16-7-9-18(28-2)19(12-16)29-3/h6-9,11-13H,4-5,10H2,1-3H3,(H,24,27)/t13-/m0/s1
• InChIKey: IZLRMTJLQCLMKF-ZDUSSCGKSA-N
• SMILES: C[C@H]1C(=NNC(=O)S1)C2=CC3=C(C=C2)N(CCC3)C(=O)C4=CC(=C(C=C4)OC)OC

EMD57439（Cat No.:I012657）is a selective small molecule inhibitor of the Rho-associated protein kinase (ROCK), a key enzyme involved in regulating cytoskeletal dynamics, cell contraction, migration, and adhesion. By inhibiting ROCK, EMD57439 can modulate cellular processes related to smooth muscle contraction, wound healing, and vascular function. It has shown potential in preclinical studies for treating conditions such as hypertension, pulmonary arterial hypertension, and fibrosis, where excessive ROCK activity contributes to pathological changes. Further research is needed to explore its therapeutic applications, safety, and efficacy in clinical settings for cardiovascular and fibrotic diseases.