For research use only. Not for therapeutic Use.
EMD638683（Cat No.:I000645）is a selective inhibitor of the enzyme protein kinase D (PKD), which plays a critical role in regulating various cellular processes, including cell survival, proliferation, and migration. By inhibiting PKD, EMD638683 has shown potential in modulating signaling pathways associated with cancer progression, inflammation, and fibrosis. It is being explored in preclinical studies for its therapeutic applications in various conditions, including cancer metastasis and cardiovascular diseases. As a PKD inhibitor, EMD638683 may help reduce abnormal cell proliferation and improve therapeutic outcomes in diseases driven by dysregulated PKD activity.
| Catalog Number | I000645 |
| CAS Number | 1181770-72-8 |
| Synonyms | N/’-[2-(3,5-difluorophenyl)-2-hydroxyacetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide |
| Molecular Formula | C18H18F2N2O4 |
| Purity | ≥95% |
| Target | SGK |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IC50 | 3 uM |
| IUPAC Name | N'-[2-(3,5-difluorophenyl)-2-hydroxyacetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide |
| InChI | InChI=1S/C18H18F2N2O4/c1-3-13-9(2)15(23)5-4-14(13)17(25)21-22-18(26)16(24)10-6-11(19)8-12(20)7-10/h4-8,16,23-24H,3H2,1-2H3,(H,21,25)(H,22,26) |
| InChIKey | SSNAPUUWBPZGOY-UHFFFAOYSA-N |
| SMILES | CCC1=C(C=CC(=C1C)O)C(=O)NNC(=O)C(C2=CC(=CC(=C2)F)F)O |
| Reference | </br>1:Inhibition of colonic tumor growth by the selective SGK inhibitor EMD638683. Towhid ST, Liu GL, Ackermann TF, Beier N, Scholz W, Fuchß T, Toulany M, Rodemann HP, Lang F.Cell Physiol Biochem. 2013;32(4):838-48. doi: 10.1159/000354486. Epub 2013 Sep 20. PMID: 24081014 Free Article</br>2:EMD638683, a novel SGK inhibitor with antihypertensive potency. Ackermann TF, Boini KM, Beier N, Scholz W, Fuchss T, Lang F.Cell Physiol Biochem. 2011;28(1):137-46. doi: 10.1159/000331722. Epub 2011 Aug 16. PMID: 21865856 Free Article |
