Emetine dihydrochloride hydrate

• CAT Number: I004655
• CAS Number: 7083-71-8
• Molecular Formula: C29H40N2O4 . 2 Cl H . x H2 O
• Purity: ≥95%
• Solubility: 5 mM in DMSO
• Storage: 2-8°C
• IUPAC Name: (2S,3R,11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizine;hydrate;dihydrochloride
• InChI: InChI=1S/C29H40N2O4.2ClH.H2O/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;;/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H;1H2/t18-,21-,24+,25-;;;/m0.../s1
• InChIKey: IZTPMTAWOCEKKM-VXMYZLRESA-N
• SMILES: CCC1CN2CCC3=CC(=C(C=C3C2CC1CC4C5=CC(=C(C=C5CCN4)OC)OC)OC)OC.O.Cl.Cl

Emetine dihydrochloride hydrate（Cat No.:I004655）, is a pharmaceutical compound used historically in the treatment of amoebiasis, a parasitic infection. It acts by inhibiting protein synthesis in the parasites, resulting in their demise. Emetine dihydrochloride hydrate is available as a hydrated form, meaning it contains water molecules in its crystal structure. Although once utilized for amoebiasis, its use has decreased due to potential toxicity and side effects, as well as the availability of more effective treatments. Therefore, alternative drugs are commonly preferred in current clinical practice for amoebiasis management.

Reference

[1]. /Matthews H, et al. Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate. Malar J. 2013 Oct 9;12:359. /
[2]. /Wu L, et al. PRRT2 truncated mutations lead to nonsense-mediated mRNA decay in Paroxysmal Kinesigenic Dyskinesia. Parkinsonism Relat Disord. 2014 Dec;20(12):1399-404. /
[3]. /Hudson LK, et al. Emetine Di-HCl attenuates Type 1 diabetes mellitus in mice. Mol Med. 2016 Jun 10;22. /
[4]. /Cornet-Masana JM, et al. Emetine induces chemosensitivity and reduces clonogenicity of acute myeloid leukemia cells. Oncotarget. 2016 Apr 26;7(17):23239-50. /