Emixustat

• CAT Number: I006659
• CAS Number: 1141777-14-1
• Molecular Formula: C16 H25 N O2
• Molecular Weight: 263.38
• Purity: ≥95%
• Synonyms: ACU 4429
• Target: visual cycle modulator
• Storage: -20°C
• Related CAS: 1141934-97-5(hydrochloride)

Emixustat(CAT: I006659) is a visual cycle modulator in development for the potential treatment of GA associated with dry AMD. Emixustat is a nonretinoid compound with a unique mode of action in the retinal pigment epithelium, where it modulates the biosynthesis of visual chromophore through its effect on retinal pigment epithelium-specific 65 kDa protein isomerase.

Reference

1: Dugel PU, Novack RL, Csaky KG, Richmond PP, Birch DG, Kubota R. Phase ii,
randomized, placebo-controlled, 90-day study of emixustat hydrochloride in
geographic atrophy associated with dry age-related macular degeneration. Retina.
2015 Jun;35(6):1173-83. doi: 10.1097/IAE.0000000000000606. PubMed PMID: 25932553;
PubMed Central PMCID: PMC4452434.

2: Kubota R, Al-Fayoumi S, Mallikaarjun S, Patil S, Bavik C, Chandler JW. Phase
1, dose-ranging study of emixustat hydrochloride (ACU-4429), a novel visual cycle
modulator, in healthy volunteers. Retina. 2014 Mar;34(3):603-9. doi:
10.1097/01.iae.0000434565.80060.f8. PubMed PMID: 24056528.