Emodin

For research use only. Not for therapeutic Use.

  • Cancer Stem Cells
  • CAT Number: I003880
  • CAS Number: 518-82-1
  • Molecular Formula: C15H10O5
  • Molecular Weight: 270.24
  • Purity: ≥95%
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Emodin (CAT: I003880) is a natural anthraquinone compound found in various plants, such as rhubarb, buckthorn, and Japanese knotweed. It exhibits diverse pharmacological activities, including anti-inflammatory, antioxidant, anticancer, and antimicrobial properties. Emodin has been investigated for its potential therapeutic effects in various diseases, including cancer, cardiovascular disorders, diabetes, and inflammatory conditions. It has been found to inhibit cell proliferation, induce apoptosis, and suppress tumor growth in preclinical studies. Additionally, emodin has shown inhibitory effects on various enzymes and signaling pathways involved in inflammation and oxidative stress.


Catalog Number I003880
CAS Number 518-82-1
Synonyms

1,3,8-trihydroxy-6-methylanthracene-9,10-dione

Molecular Formula C15H10O5
Purity ≥95%
Target NF-κB
Solubility DMSO: ≤ 9.4 mg/mL
Storage 3 years -20C powder
Overview of Clinical Research

Emodin is a DNA synthesis inhibitor used for treating cancer.

IC50 observed at 72 hr were as follows: 66.9 uM, Hep3B cells; 74.36 uM, HepG2 cells; and 101.5 uM, Huh7 cells [1].
IUPAC Name 1,3,8-trihydroxy-6-methylanthracene-9,10-dione
InChI InChI=1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
InChIKey RHMXXJGYXNZAPX-UHFFFAOYSA-N
SMILES CC1=CC(=C2C(=C1)C(=O)C3=CC(=CC(=C3C2=O)O)O)O
Reference

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<span style=”font-family:arial,helvetica,sans-serif;”><span style=”font-size:12px;”>1.The effect of aloe-emodin-induced photodynamic activity on the apoptosis of human gastric cancer cells: A pilot study. Lin HD, Li KT, Duan QQ, Chen Q, Tian S, Chu ESM, Bai DQ.Oncol Lett. 2017 May;13(5):3431-3436. doi: 10.3892/ol.2017.5915. Epub 2017 Mar 27. PMID: 28521449<br />
2.Screening of a natural compound library identifies emodin, a natural compound from <i>Rheum palmatum</i> Linn that inhibits DPP4. Wang Z, Yang L, Fan H, Wu P, Zhang F, Zhang C, Liu W, Li M.PeerJ. 2017 May 10;5:e3283. doi: 10.7717/peerj.3283. eCollection 2017. PMID: 28507818 Free PMC Article<br />
3.INHIBITORY EFFECT OF EMODIN ON RAW 264.7 ACTIVATED WITH DOUBLE STRANDED RNA ANALOGUE POLY I:C. Kim YJ, Lee JY, Kim HJ, Kim DH, Lee TH, Kang MS, Choi YK, Lee HL, Kim J, An HJ, Park AW.Afr J Tradit Complement Altern Med. 2017 Mar 1;14(3):157-166. doi: 10.21010/ajtcam.v14i3.17. eCollection 2017. PMID: 28480427<br />
4.EMODIN EFFICACY ON THE AKT, MAPK, ERK AND DNMT EXPRESSION PATTERN DURING DMBA-INDUCED ORAL CARCINOMA IN GOLDEN SYRIAN HAMSTERS. Manimaran A, Manoharan S, Neelakandan M.Afr J Tradit Complement Altern Med. 2016 Sep 29;13(6):186-193. doi: 10.21010/ajtcam.v13i6.27. eCollection 2016. PMID: 28480378<br />
5.Aloe-emodin Induces Apoptosis in Human Liver HL-7702 Cells through Fas Death Pathway and the Mitochondrial Pathway by Generating Reactive Oxygen Species. Dong X, Fu J, Yin X, Yang C, Ni J.Phytother Res. 2017 Apr 26. doi: 10.1002/ptr.5820. [Epub ahead of print] PMID: 28444790<br />
6.Selective emodin toxicity in cancer cells. Kolitsida P, Abeliovich H.Oncotarget. 2017 Mar 27. doi: 10.18632/oncotarget.16611. [Epub ahead of print] No abstract available. PMID: 28415655 Free Article<br />
7.Respiratory status determines the effect of emodin on cell viability. Dumit VI, Zerbes RM, Kaeser-Pebernard S, Rackiewicz M, Wall MT, Gretzmeier C, K&uuml;ttner V, van der Laan M, Braun RJ, Dengjel J.Oncotarget. 2017 Mar 21. doi: 10.18632/oncotarget.16396. [Epub ahead of print] PMID: 28415582 Free Article<br />
8.Emodin suppresses the nasopharyngeal carcinoma cells by targeting the chloride channels. Ma L, Yang Y, Yin Z, Liu M, Wang L, Chen L, Zhu L, Yang H.Biomed Pharmacother. 2017 Jun;90:615-625. doi: 10.1016/j.biopha.2017.03.088. Epub 2017 Apr 12. PMID: 28411554<br />
9.Study on synthesis and bioactivity of biotinylated emodin. Hou X, Wei W, Fan Y, Zhang J, Zhu N, Hong H, Wang C.Appl Microbiol Biotechnol. 2017 Apr 6. doi: 10.1007/s00253-017-8243-3. [Epub ahead of print] PMID: 28386632<br />
10.Emodin targets mitochondrial cyclophilin D to induce apoptosis in HepG2 cells. Zhang L, He D, Li K, Liu H, Wang B, Zheng L, Li J.Biomed Pharmacother. 2017 Jun;90:222-228. doi: 10.1016/j.biopha.2017.03.046. Epub 2017 Mar 28. PMID: 28363167</span></span>

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