For research use only. Not for therapeutic Use.
Empesertib (BAY 1161909) is a potent Mps1 inhibitor, with an IC50 of < 1 nM.
BAY 1161909 is a potent Mps1 inhibitor, with an IC50 of < 1 nM. BAY 1161909 also shows anti-tumor effect, suppressing the proliferation of Hela cells, with an IC50 of < 400 nM[1].
| Catalog Number | I006661 |
| CAS Number | 1443763-60-7 |
| Synonyms | (2R)-2-(4-fluorophenyl)-N-[4-[2-(2-methoxy-4-methylsulfonylanilino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]phenyl]propanamide |
| Molecular Formula | C29H26FN5O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C29H26FN5O4S/c1-18(19-4-9-22(30)10-5-19)28(36)31-23-11-6-20(7-12-23)21-8-15-27-33-29(34-35(27)17-21)32-25-14-13-24(40(3,37)38)16-26(25)39-2/h4-18H,1-3H3,(H,31,36)(H,32,34)/t18-/m1/s1 |
| InChIKey | NRJKIOCCERLIDG-GOSISDBHSA-N |
| SMILES | CC(C1=CC=C(C=C1)F)C(=O)NC2=CC=C(C=C2)C3=CN4C(=NC(=N4)NC5=C(C=C(C=C5)S(=O)(=O)C)OC)C=C3 |
| Reference | [1]. SCHULZE, Volker, et al. PRODRUG DERIVATIVES OF SUBSTITUTED TRIAZOLOPYRIDINES. WO2014198647A2 |
