For research use only. Not for therapeutic Use.
EMT inhibitor-2 (Compound 1) inhibits epithelial-mesenchymal transition (EMT) induced by substances such as IL-1β and TGF-β released from the immunocytes. EMT inhibitor-2 inhibits CYP3A4 testosteron and CYP2C9 with IC50s of 49.72 and 5.54 μM, respectively[1].
| Catalog Number | I018599 |
| CAS Number | 2232228-60-1 |
| Synonyms | 4-[2-[2-(3,4-dimethoxyphenyl)-5-hydroxy-6-methoxy-4-oxochromen-7-yl]oxyethyl]piperazin-2-one |
| Molecular Formula | C24H26N2O8 |
| Purity | ≥95% |
| InChI | InChI=1S/C24H26N2O8/c1-30-16-5-4-14(10-18(16)31-2)17-11-15(27)22-19(34-17)12-20(24(32-3)23(22)29)33-9-8-26-7-6-25-21(28)13-26/h4-5,10-12,29H,6-9,13H2,1-3H3,(H,25,28) |
| InChIKey | QOLZDEMWVAPPHO-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C(=C(C=C3O2)OCCN4CCNC(=O)C4)OC)O)OC |
| Reference | [1]. Youn, Byung Soo, et al. Substituted chromenes for treatment of fibrosis or non-alcoholic steatohepatitis. US10370364. |
