For research use only. Not for therapeutic Use.
EN106 is a potent inhibitor of FEMIB. EN106 is a cysteine-reactive covalent ligand. EN106 disrupts recognition of the key reductive stress substrate of FEM1B, FNIP1[1].
| Catalog Number | I043743 |
| CAS Number | 757192-67-9 |
| Synonyms | 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)acetamide |
| Molecular Formula | C13H13ClN2O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C13H13ClN2O3/c14-9-13(17)16(5-1-4-15)10-2-3-11-12(8-10)19-7-6-18-11/h2-3,8H,1,5-7,9H2 |
| InChIKey | GLDJSVHDOXCYPT-UHFFFAOYSA-N |
| SMILES | C1COC2=C(O1)C=CC(=C2)N(CCC#N)C(=O)CCl |
| Reference | [1]. Henning NJ, et al. Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications. J Am Chem Soc. 2022;144(2):701-708. |
