EN450

• CAT Number: I040868
• CAS Number: 793719-01-4
• Molecular Formula: C11H13ClN2O3S
• Molecular Weight: 288.75
• Purity: ≥95%
• Synonyms: N-[2-chloro-5-(dimethylsulfamoyl)phenyl]prop-2-enamide
• InChI: InChI=1S/C11H13ClN2O3S/c1-4-11(15)13-10-7-8(5-6-9(10)12)18(16,17)14(2)3/h4-7H,1H2,2-3H3,(H,13,15)
• InChIKey: OXFXDOLAQBMOPH-UHFFFAOYSA-N
• SMILES: CN(C)S(=O)(=O)C1=CC(=C(C=C1)Cl)NC(=O)C=C

EN450(CAT: I040868) is a cysteine-reactive covalent molecular glue degrader that targets NF-κB, a key regulator in immune response and inflammation. It specifically interacts with the allosteric cysteine residue (C111) in the E2 ubiquitin ligase UBE2D, facilitating the formation of a ternary complex between UBE2D and NF-κB1. This interaction promotes the ubiquitination and subsequent degradation of NF-κB1 via the Cullin E3 ligase complex and the proteasome. EN450 exhibits potent anti-proliferative effects by disrupting NF-κB signaling, which plays a crucial role in cancer cell survival, inflammation, and immune regulation, making it a promising candidate in Cancer Disease Research.