For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>EN460 is a small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1); interacts selectively(IC50=1.9 uM) with the reduced, active form of ERO1α and prevents its reoxidation.<br>IC50 value: 1.9 uM [1]<br>Target: ERO1 inhibitor<br>in vitro: Exposure of cells to EN460 or QM295 resulted in the accumulation of an ERO1α form with lower mobility, indicative of the reduced state. EN460 and QM295 were also found to activate an unfolded protein response reporter in cultured 293T cells.</p>
| Catalog Number | I003743 |
| CAS Number | 496807-64-8 |
| Molecular Formula | C22H12ClF3N2O4 |
| Purity | ≥95% |
| Target | ERO1 inhibitor |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IC50 | 1.9 uM [1] |
| InChI | InChI=1S/C22H12ClF3N2O4/c23-17-8-6-13(10-15(17)21(30)31)28-20(29)16(19(27-28)22(24,25)26)11-14-7-9-18(32-14)12-4-2-1-3-5-12/h1-11H,(H,30,31)/b16-11- |
| InChIKey | RSLFQCNAOMQAIH-WJDWOHSUSA-N |
| SMILES | O=C(O)C1=CC(N2N=C(C(F)(F)F)/C(C2=O)=C/C3=CC=C(C4=CC=CC=C4)O3)=CC=C1Cl |
| Reference | <p style=/line-height:25px/> </p> |
